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Non-N-Methyl-D-Aspartate Glutamate Receptors in the Paraventricular Nucleus of Hypothalamus Mediate the Pressor Response Evoked by Noradrenaline Microinjected Into the Lateral Septal Area in Rats

Scopinho, America Augusto; Tavares, Rodrigo Fiacadori; Busnardo, Cristiane; Correa, Fernando Morgan Aguiar Universidade De São Paulo

JOURNAL OF NEUROSCIENCE RESEARCH, v.86, n.14, p.3203-3211, 2008

WILEY-LISS 2008

Acesso online

  • Título:
    Non-N-Methyl-D-Aspartate Glutamate Receptors in the Paraventricular Nucleus of Hypothalamus Mediate the Pressor Response Evoked by Noradrenaline Microinjected Into the Lateral Septal Area in Rats
  • Autor: Scopinho, America Augusto; Tavares, Rodrigo Fiacadori; Busnardo, Cristiane; Correa, Fernando Morgan Aguiar
  • Universidade De São Paulo
  • Assuntos: Paraventricular Nucleus Of Hypothalamus; Vasopressin Release; Noradrenaline; Lateral Septal Area; Glutamate; Non-Nmda Receptors; Unanesthetized Rats; Cardiovascular-Responses; Supraoptic Nucleus; Vasopressin Release; Stria Terminalis; Bed Nucleus; Oxytocin; Forebrain; Brain; Neurosciences
  • É parte de: JOURNAL OF NEUROSCIENCE RESEARCH, v.86, n.14, p.3203-3211, 2008
  • Descrição: The lateral septal area (LSA) is a part of the limbic system and is involved in cardiovascular modulation. We previously reported that microinjection of noradrenaline (NA) into the LSA of unanesthetized rats caused pressor responses that are mediated by acute vasopressin release. Magnocellular neurons of the paraventricular (PVN) and supraoptic (SON) of the hypothalamus synthesize vasopressin. In the present work, we studied which of these nuclei is involved in the pressor pathway activated by unilateral NA injection into the LSA as well as the local neurotransmitter involved. Chemical ablation of the SON by unilateral injection of the nonspecific synapses blocker cobalt chloride (1 mM/100 nl) did not affect the pressor response evoked by NA (21 nmol/200 nl) microinjection into the LSA. However, the response to NA was blocked when cobalt chloride (1 mM/100 nl) was microinjected into the PVN, indicating that this hypothalamic nucleus is responsible for the mediation of the pressor response. There is evidence in the literature pointing to glutamate as a putative neurotransmitter activating magnocellular neurons. Pretreatment of the PVN with the selective non-N-methyl-D-asparate (NMDA) antagonist NBQX (2 nmol/100 nl) blocked the pressor response to NA microinjected into the LSA, whereas pretreatment with the selective NMDA antagonist LY235959 (2 nmol/100 nl) did not affect the response to NA. Our results implicate the PVN as the final structure in the pressor pathway activated by the microinjection of NA into the LSA. They also indicate that local glutamatergic synapses and non-NMDA glutamatergic receptors mediate the response in the PVN. (c) 2008 Wiley-Liss, Inc.
    CNPq[151388/2007-5]
    CNPq[478919/2007-7]
    Fapesp[06/52446-9]
  • DOI: 10.1002/jnr.21756
  • Títulos relacionados: Journal of Neuroscience Research
  • Editor: WILEY-LISS
  • Data de publicação: 2008
  • Idioma: Inglês

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