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FASN expression, angiogenesis and lymphangiogenesis in central and peripheral giant cell lesions

Falci, Saulo Gabriel Moreira; Mesquita, Ana Terezinha Marques; Andrade, Bruno Augusto Benevenuto De; Miranda, Joao Luiz De; León, Jorge Esquiche; Almeida, Oslei Paes De; Santos, Cássio Roberto Rocha Dos

Journal of Applied Oral Science; v. 22, n. 2 (2014); 131-137

Universidade de São Paulo. Faculdade de Odontologia de Bauru 2014-04-01

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  • Título:
    FASN expression, angiogenesis and lymphangiogenesis in central and peripheral giant cell lesions
  • Autor: Falci, Saulo Gabriel Moreira; Mesquita, Ana Terezinha Marques; Andrade, Bruno Augusto Benevenuto De; Miranda, Joao Luiz De; León, Jorge Esquiche; Almeida, Oslei Paes De; Santos, Cássio Roberto Rocha Dos
  • É parte de: Journal of Applied Oral Science; v. 22, n. 2 (2014); 131-137
  • Descrição: Central giant cell lesion (CGCL) and peripheral giant cell lesion (PGCL) are non-neoplastic proliferative processes of the jaws. PGCL is a reactive process induced by irritant local factors and CGCL is an intra-osseous lesion of unknown etiology. Both lesions exhibit similar histologic features showing abundant mononuclear cells, admixed with a large number of multinucleated giant cells and a rich vascularized stroma with extravasated erythrocytes, hemosiderin deposition, and blood-filled pools. Recent studies have linked fatty acid synthase (FASN) with angiogenesis. Objective: To evaluate angiogenesis and lymphangiogenesis and their relationship with FASN expression in CGCL and PGCL. Material and Methods: Thirteen CGCL and 14 PGCL of the jaws were selected for immunoexpression of FASN; CD34 and CD105 (to assess blood microvessel density [MVD] and microvessel area [MVA]); and D2-40 (to assess lymphatic MVD and MVA). Results: Within PGCL and CGCL, MVD-CD34 was signifcantly higher than MVD-CD10S, followed by MVD-D2-40. Moreover, a signifcantly higher number of FASN-positive multinucleated giant cells than mononuclear cells were observed. Between PGCL and CGCL, only MVD-CD34 and all MVA were signifcantly higher in PGCL. Positive correlation between MVA-CD10S with FASNpositive mononuclear cells in both lesions was observed. Conclusions: Our results show both lesions exhibiting similar levels of FASN expression and neoangiogenesis, suggesting constitutive processes that regulate tissue maintenance.
  • DOI: 10.1590/1678-775720130509
    10.1590/1678-7757201130509
  • Títulos relacionados: https://www.revistas.usp.br/jaos/article/view/80555/84218
  • Editor: Universidade de São Paulo. Faculdade de Odontologia de Bauru
  • Data de publicação: 2014-04-01
  • Formato: Adobe PDF
  • Idioma: Inglês

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