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Using fluid bed granulation to improve the dissolution of poorly water-soluble drugs

Takahashi, andrea Ikeda; Lourenço, Felipe Rebello; Duque, marcelo Dutra; Consiglieri, Vladi Olga; Ferraz, Humberto Gomes Universidade De São Paulo

Braz. arch. biol. technol.,v.55,n.3,p.477-484,2012

Brazilian Archives of Biology and Technology 2012

Acesso online

  • Título:
    Using fluid bed granulation to improve the dissolution of poorly water-soluble drugs
  • Autor: Takahashi, andrea Ikeda; Lourenço, Felipe Rebello; Duque, marcelo Dutra; Consiglieri, Vladi Olga; Ferraz, Humberto Gomes
  • Universidade De São Paulo
  • Assuntos: Fluid Bed; Granulation; Dissolution Efficiency; Nimodipine; Spironolactone
  • É parte de: Braz. arch. biol. technol.,v.55,n.3,p.477-484,2012
  • Descrição: In this study, fluid bed granulation was applied to improve the dissolution of nimodipine and spironolactone, two very poorly water-soluble drugs. Granules were obtained with different amounts of sodium dodecyl sulfate and croscarmellose sodium and then compressed into tablets. The dissolution behavior of the tablets was studied by comparing their dissolution profiles and dissolution efficiency with those obtained from physical mixtures of the drug and excipients subjected to similar conditions. Statistical analysis of the results demonstrated that the fluid bed granulation process improves the dissolution efficiency of both nimodipine and spironolactone tablets. The addition of either the surfactant or the disintegrant employed in the study proved to have a lower impact on this improvement in dissolution than the fluid bed granulation process.
  • DOI: 10.1590/S1516-89132012000300020
  • Títulos relacionados: Brazilian Archives of Biology and Technology
  • Editor: Brazilian Archives of Biology and Technology
  • Data de publicação: 2012
  • Idioma: Inglês

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