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Menstrual and hormonal alterations in juvenile systemic lupus erythematosus

Medeiros, P. B.; Febronio, M. V.; Bonfa, E.; Borba, E. F.; Takiuti, A. D.; Silva, C. A. A. Universidade De São Paulo

LUPUS, v.18, n.1, p.38-43, 2009

SAGE PUBLICATIONS LTD 2009

Acesso online

  • Título:
    Menstrual and hormonal alterations in juvenile systemic lupus erythematosus
  • Autor: Medeiros, P. B.; Febronio, M. V.; Bonfa, E.; Borba, E. F.; Takiuti, A. D.; Silva, C. A. A.
  • Universidade De São Paulo
  • Assuntos: Adolescent; Hormone; Juvenile Systemic Lupus Erythematosus; Menarche; Menstrual Abnormalities; Ovarian Failure; Risk-Factors; Disease-Activity; Cyclophosphamide Therapy; Pulse Cyclophosphamide; Childhood; Women; Amenorrhea; Rheumatology
  • É parte de: LUPUS, v.18, n.1, p.38-43, 2009
  • Descrição: Menstrual cycles of 30 patients with juvenile systemic lupus erythematosus (JSLE) were compared with 30 age-matched controls. The mean age of patients with JSLE and controls was similar (17.4 +/- 3.2 vs 17.06 +/- 2.08 years, P = 0.66). The mean menarche age was higher in JSLE than controls (13.13 +/- 1.4 vs 11.56 +/- 1.5 years, P = 0.0008). On the contrary, the mean maternal menarche age was similar in both groups (P = 0.62). Menstrual abnormalities and longer length cycles were more frequently observed in JSLE than controls (63% vs 10%, P = 0.0001; 23% vs 0%, P = 0.0105, respectively). The median of follicle stimulating hormone was significantly higher in patients with JSLE compared with controls (4.6 vs 3.4 IU/L, P = 0.0207), and the median of progesterone was lower (32.5 vs 70 ng/mL, P = 0.0033). The median Of luteinizing hormone was lower in patients with JSLE with menstrual abnormalities versus normal cycles (2.9 vs 5.5 IU/L, P = 0.019) and both had a high percentage of decreased progesterone levels (63% vs 73%, P = 0.70). Our findings support the notion that menstrual disturbances are frequent and may be associated with pituitary dysfunction leading to a decreased progesterone production. We also reported that in spite of premature ovarian failure being a rare event in JSLE the follicular reserve seems to be low regardless of intravenous cyclophosphamide treatment. Lupus (2009) 18, 38-43.
    Conselho Nacional de Desenvolvimento Clentifico e Tecnologico - CNPQ[305468/2006-5]
    Conselho Nacional de Desenvolvimento Clentifico e Tecnologico - CNPQ[302469/2005-2]
    Federico Foundation
  • DOI: 10.1177/0961203308094652
    10.6061/clinics/2012(11)09
    10.1177/0961203310378412
    10.1177/0961203308100559
    10.1590/S0482-50042009000400004
    10.1007/s00296-011-1918-7
    10.1590/S0482-50042010000400003
    10.1177/0961203310392428
  • Títulos relacionados: Lupus
  • Editor: SAGE PUBLICATIONS LTD
  • Data de publicação: 2009
  • Idioma: Inglês

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