skip to main content

Useful laboratory markers for the diagnosis of bone marrow involvement by malignant lymphoma

Nishimura, K. ; Ota, R. ; Mikajiri, Y. ; Takahashi, K. ; Sugishima, S. ; Eto, T.

International Journal of Laboratory Hematology, February 2018, Vol.40(1), pp.34-40 [Periódico revisado por pares]

Texto completo disponível

Citações Citado por
  • Título:
    Useful laboratory markers for the diagnosis of bone marrow involvement by malignant lymphoma
  • Autor: Nishimura, K. ; Ota, R. ; Mikajiri, Y. ; Takahashi, K. ; Sugishima, S. ; Eto, T.
  • Assuntos: Bone Marrow Involvement ; Diagnostic Value ; Laboratory Marker ; Lymphoma ; Receiver Operating Characteristic
  • É parte de: International Journal of Laboratory Hematology, February 2018, Vol.40(1), pp.34-40
  • Descrição: Byline: K. Nishimura, R. Ota, Y. Mikajiri, K. Takahashi, S. Sugishima, T. Eto Keywords: bone marrow involvement; diagnostic value; laboratory marker; lymphoma; receiver operating characteristic Abstract Introduction This study aimed to investigate the effect of bone marrow involvement by malignant lymphoma (BMI) on laboratory data and to determine the useful laboratory markers for diagnosing BMI. Methods We compared laboratory data between patients with and without BMI. We performed multivariate logistic regression and receiver operating characteristic (ROC) analyses to evaluate the diagnostic values of independent predictors. Results In the BMI group, platelets in peripheral blood (PLT) and megakaryocyte count in bone marrow (MgK) were significantly lower than those in the non-BMI group (PLT, P < .0001; MgK, P = .0384). The rate of peripheral blood involvement by malignant lymphoma (PBI), red blood cell distribution width (RDW), D-dimer (DD), soluble interleukin-2 receptor (sIL2R), aspartate aminotransferase (AST), and lactate dehydrogenase (LDH) was significantly higher in the BMI group than in the non-BMI group (PBI, P < .0001; RDW, P = .0190; DD, P = .0006; sIL2R, P < .0001; AST, P = .0256; LDH, P = .0002). In multivariate analysis, PBI, PLT, sIL2R, and MgK levels were independent predictors of BMI. Conclusion PBI, PLT, sIL2R, and MgK may be the useful laboratory markers for BMI diagnosis.

Buscando em bases de dados remotas. Favor aguardar.