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Impaired antioxidant HDL function is associated with premature myocardial infarction

Distelmaier, Klaus ; Wiesbauer, Franz ; Blessberger, Hermann ; Oravec, Stanislav ; Schrutka, Lore ; Binder, Christina ; Dostal, Elisabeth ; Schillinger, Martin ; Wojta, Johann ; Lang, Irene M. ; Maurer, Gerald ; Huber, Kurt ; Goliasch, Georg

European Journal of Clinical Investigation, July 2015, Vol.45(7), pp.731-738 [Periódico revisado por pares]

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  • Título:
    Impaired antioxidant HDL function is associated with premature myocardial infarction
  • Autor: Distelmaier, Klaus ; Wiesbauer, Franz ; Blessberger, Hermann ; Oravec, Stanislav ; Schrutka, Lore ; Binder, Christina ; Dostal, Elisabeth ; Schillinger, Martin ; Wojta, Johann ; Lang, Irene M. ; Maurer, Gerald ; Huber, Kurt ; Goliasch, Georg
  • Assuntos: Acute Myocardial Infarction ; Antioxidant Function ; High‐Density Lipoprotein ; Premature Coronary Artery Disease
  • É parte de: European Journal of Clinical Investigation, July 2015, Vol.45(7), pp.731-738
  • Descrição: To purchase or authenticate to the full-text of this article, please visit this link: http://onlinelibrary.wiley.com/doi/10.1111/eci.12466/abstract Byline: Klaus Distelmaier, Franz Wiesbauer, Hermann Blessberger, Stanislav Oravec, Lore Schrutka, Christina Binder, Elisabeth Dostal, Martin Schillinger, Johann Wojta, Irene M. Lang, Gerald Maurer, Kurt Huber, Georg Goliasch Keywords: Acute myocardial infarction; antioxidant function; high-density lipoprotein; premature coronary artery disease Abstract Background There is growing evidence that the predictive value of HDL cholesterol levels for cardiovascular risk stratification is limited in patients with coronary artery disease (CAD). HDL function seems to be a more sensitive surrogate of cardiovascular risk estimation than simple serum levels. Therefore, we aimed to assess whether impaired antioxidant HDL function is involved in the development of premature acute myocardial infarction (AMI). Methods In this multicentre case-control study, we compared the antioxidant function of HDL, measured by the HDL inflammatory index (HII), and HDL particle size in 184 patients comprising 92 patients with AMI at a very young age ([less than or equal to]40 years of age) and 92 age- and gender-matched controls. Results Antioxidant capacities of HDL were significantly impaired in the acute phase of AMI (HII of 1ae50 [IQR 1ae10-1ae74] vs. 0ae56 [IQR 0ae41-0ae86] in controls, P < 0ae001 as well as in the chronic stable phase 1 year after the event (HII of 0ae85 [IQR 0ae72-1ae03] vs. 0ae56 [IQR 0ae41-0ae86], P < 0ae001) compared to controls. Moreover, HDL function in the stable phase remained significantly associated with premature MI in adjusted logistic regression analysis with an OR of 2ae24 per SD increase of HII (95% CI 1ae28-3ae91; P = 0ae005). Analyses of HDL size revealed a significant correlation between all HDL subfractions and HDL function in controls, whereas this correlation was lost for large and intermediate HDL in AMI patients. Conclusion Impaired antioxidant function of HDL is independently associated with the development of premature AMI. The maintenance of HDL function might evolve into a significant therapeutic target, especially in patients with premature CAD.

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