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Antimicrobial Resistance to Agents Used for Staphylococcus aureus Decolonization: Is There a Reason for Concern?

Madden, Gregory ; Sifri, Costi

Current Infectious Disease Reports, 2018, Vol.20(8), pp.1-11 [Periódico revisado por pares]

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  • Título:
    Antimicrobial Resistance to Agents Used for Staphylococcus aureus Decolonization: Is There a Reason for Concern?
  • Autor: Madden, Gregory ; Sifri, Costi
  • Assuntos: Antimicrobial resistance ; Antiseptic ; Chlorhexidine ; Mupirocin ; Decolonization ; Staphylococcus aureus
  • É parte de: Current Infectious Disease Reports, 2018, Vol.20(8), pp.1-11
  • Descrição: To access, purchase, authenticate, or subscribe to the full-text of this article, please visit this link: http://dx.doi.org/10.1007/s11908-018-0630-0 Byline: Gregory R. Madden (1), Costi D. Sifri (1,2) Keywords: Antimicrobial resistance; Antiseptic; Chlorhexidine; Mupirocin; Decolonization; Staphylococcus aureus Abstract: Purpose of Review Chlorhexidine gluconate (CHG) and mupirocin are increasingly used for Staphylococcus aureus decolonization to prevent healthcare-associated infections however, increased use of these agents has led to concerns for growing resistance and reduced efficacy. In this review, we describe current understanding of reduced susceptibility to CHG and mupirocin in S. aureus and their potential clinical implications. Recent Findings While emergence of S. aureus tolerant or resistant to topical antimicrobial agents used for decolonization is well described, the clinical impact of reduced susceptibility is not clear. Important challenges are that standardized methods of resistance testing and interpretation are not established, and the risk for selection for co- or cross-resistance using universal, as opposed to targeted decolonization, is unclear. Summary Evidence continues to support S. aureus decolonization in certain patient groups, although further studies are needed to determine the long-term impact of CHG and mupirocin resistance on efficacy. Strategies to mitigate further development of reduced susceptibility and the consequences of selection pressures through universal decolonization on resistance will benefit from further investigation. Author Affiliation: (1) 0000 0004 1936 9932, grid.412587.d, Division of Infectious Diseases & International Health, Department of Medicine, University of Virginia Health System, Charlottesville, VA, USA (2) 0000 0004 1936 9932, grid.412587.d, Office of Hospital Epidemiology/Infection Prevention & Control, University of Virginia Health System, P.O. Box 800473, Charlottesville, VA, 22908-0473, USA Article History: Registration Date: 14/05/2018 Online Date: 07/06/2018 Article note: This article is part of the Topical Collection on Antimicrobial Development and Drug Resistance
  • Idioma: Inglês

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