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Aortic root dimensions are predominantly determined by genetic factors: a classical twin study

Celeng, Csilla ; Kolossváry, Márton ; Kovács, Attila ; Molnár, Andrea ; Szilveszter, Bálint ; Horváth, Tamás ; Károlyi, Mihály ; Jermendy, Ádám ; Tárnoki, Ádám ; Tárnoki, Dávid ; Karády, Júlia ; Voros, Szilard ; Jermendy, György ; Merkely, Béla ; Maurovich-Horvat, Pál

European Radiology, 2017, Vol.27(6), pp.2419-2425 [Periódico revisado por pares]

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  • Título:
    Aortic root dimensions are predominantly determined by genetic factors: a classical twin study
  • Autor: Celeng, Csilla ; Kolossváry, Márton ; Kovács, Attila ; Molnár, Andrea ; Szilveszter, Bálint ; Horváth, Tamás ; Károlyi, Mihály ; Jermendy, Ádám ; Tárnoki, Ádám ; Tárnoki, Dávid ; Karády, Júlia ; Voros, Szilard ; Jermendy, György ; Merkely, Béla ; Maurovich-Horvat, Pál
  • Assuntos: Ascending aorta ; Multidetector computed tomography ; Transthoracic echocardiography ; Twins ; Genetic determinism
  • É parte de: European Radiology, 2017, Vol.27(6), pp.2419-2425
  • Descrição: To access, purchase, authenticate, or subscribe to the full-text of this article, please visit this link: http://dx.doi.org/10.1007/s00330-016-4590-1 Byline: Csilla Celeng (1), Marton Kolossvary (1), Attila Kovacs (1), Andrea Agnes Molnar (1), Balint Szilveszter (1), Tamas Horvath (2), Mihaly Karolyi (1), Adam L. Jermendy (1), Adam D. Tarnoki (3), David L. Tarnoki (3), Julia Karady (1), Szilard Voros (4), Gyorgy Jermendy (5), Bela Merkely (1), Pal Maurovich-Horvat (1) Keywords: Ascending aorta; Multidetector computed tomography; Transthoracic echocardiography; Twins; Genetic determinism Abstract: Objectives Previous studies using transthoracic echocardiography (TTE) observed moderate heritability of aortic root dimensions. Computed tomography angiography (CTA) might provide more accurate heritability estimates. Our primary aim was to assess the heritability of the aortic root with CTA. Our secondary aim was to derive TTE-based heritability and compare this with the CTA-based results. Methods In the BUDAPEST-GLOBAL study 198 twin subjects (118 monozygotic, 80 dizygotic age 56.1[+ or -]9.4 years 126 female) underwent CTA and TTE. We assessed the diameter of the left ventricular outflow tract (LVOT), annulus, sinus of Valsalva, sinotubular junction and ascending aorta. Heritability was assessed using ACDE model (A additive genetic, C common environmental, D dominant genetic, E unique environmental factors). Results Based on CTA, additive genetic effects were dominant (LVOT: A=0.67, E=0.33 annulus: A=0.76, E=0.24 sinus of Valsalva: A=0.83, E=0.17 sinotubular junction: A=0.82, E=0.18 ascending aorta: A=0.75, E=0.25). TTE-derived measurements showed moderate to no genetic influence (LVOT: A=0.38, E=0.62 annulus: C=0.47, E=0.53 sinus of Valsalva: C=0.63, E=0.37 sinotubular junction: C=0.45, E=0.55 ascending aorta: A=0.67, E=0.33). Conclusion CTA-based assessment suggests that aortic root dimensions are predominantly determined by genetic factors. TTE-based measurements showed moderate to no genetic influence. The choice of measurement method has substantial impact on heritability estimates. Key Points acents Aortic root dimensions are determined by genetic and environmental effects. acents Transthoracic echocardiography (TTE) demonstrated moderate to no genetic effects on aortic root dimensions. acents Computed tomography angiography might provide more accurate heritability estimates compared to TTE. acents Three-dimensional imaging techniques are needed to reliably quantify aortic root dimensions. Author Affiliation: (1) MTA-SE Cardiovascular Imaging Research Group, Heart and Vascular Center, Semmelweis University, Varosmajor St. 68, H-1122, Budapest, Hungary (2) Department of Hydrodynamic Systems, Budapest University of Technology and Economics, Budapest, Hungary (3) Department of Radiology and Oncotherapy, Semmelweis University, Budapest, Hungary (4) Global Genomics Group, Atlanta, GA, USA (5) Medical Department, Bajcsy-Zsilinszky Hospital, Budapest, Hungary Article History: Registration Date: 29/08/2016 Received Date: 22/03/2016 Accepted Date: 29/08/2016 Online Date: 22/09/2016 Article note: Bela Merkely and Pal Maurovich-Horvat contributed equally to this work. Electronic supplementary material The online version of this article (doi: 10.1007/s00330-016-4590-1) contains supplementary material, which is available to authorized users.
  • Idioma: Inglês

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