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Temperature dependence of postmortem MR quantification for soft tissue discrimination

Zech, Wolf-Dieter ; Schwendener, Nicole ; Persson, Anders ; Warntjes, Marcel ; Jackowski, Christian

European Radiology, 2015, Vol.25(8), pp.2381-2389 [Periódico revisado por pares]

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  • Título:
    Temperature dependence of postmortem MR quantification for soft tissue discrimination
  • Autor: Zech, Wolf-Dieter ; Schwendener, Nicole ; Persson, Anders ; Warntjes, Marcel ; Jackowski, Christian
  • Assuntos: Postmortem magnetic resonance imaging ; Quantitative MRI ; MRI temperature dependence ; Soft tissue ; Thoraco-abdominal organs
  • É parte de: European Radiology, 2015, Vol.25(8), pp.2381-2389
  • Descrição: Byline: Wolf-Dieter Zech (1), Nicole Schwendener (1), Anders Persson (2), Marcel J. Warntjes (2), Christian Jackowski (1) Keywords: Postmortem magnetic resonance imaging; Quantitative MRI; MRI temperature dependence; Soft tissue; Thoraco-abdominal organs Abstract: Objectives To investigate and correct the temperature dependence of postmortem MR quantification used for soft tissue characterization and differentiation in thoraco-abdominal organs. Material and methods Thirty-five postmortem short axis cardiac 3-T MR examinations were quantified using a quantification sequence. Liver, spleen, left ventricular myocardium, pectoralis muscle and subcutaneous fat were analysed in cardiac short axis images to obtain mean T1, T2 and PD tissue values. The core body temperature was measured using a rectally inserted thermometer. The tissue-specific quantitative values were related to the body core temperature. Equations to correct for temperature differences were generated. Results In a 3D plot comprising the combined data of T1, T2 and PD, different organs/tissues could be well differentiated from each other. The quantitative values were influenced by the temperature. T1 in particular exhibited strong temperature dependence. The correction of quantitative values to a temperature of 37 [degrees]C resulted in better tissue discrimination. Conclusion Postmortem MR quantification is feasible for soft tissue discrimination and characterization of thoraco-abdominal organs. This provides a base for computer-aided diagnosis and detection of tissue lesions. The temperature dependence of the T1 values challenges postmortem MR quantification. Equations to correct for the temperature dependence are provided. Key points acents Postmortem MR quantification is feasible for soft tissue discrimination and characterization acents Temperature dependence of the T1 values challenges the MR quantification approach acents The results provide the basis for computer-aided postmortem MRI diagnosis acents Diagnostic criteria may also be applied for living patients Author Affiliation: (1) From the Institute of Forensic Medicine, University of Bern, Buehlstrasse 20, 3012, Bern, Switzerland (2) The Center for Medical Image Science and Visualization (CMIV), University of Linkoping, 58185, Linkoping, Sweden Article History: Registration Date: 08/01/2015 Received Date: 06/05/2014 Accepted Date: 08/01/2015 Online Date: 01/02/2015
  • Idioma: Inglês

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