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Durable mechanical circulatory support in teenagers and adults with congenital heart disease: A systematic review

Steiner, Jill M. ; Krieger, Eric V. ; Stout, Karen K. ; Stempien-Otero, April ; Mahr, Claudius ; Mokadam, Nahush A. ; Hermsen, Joshua L.

International Journal of Cardiology, 15 October 2017, Vol.245, pp.135-140 [Periódico revisado por pares]

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  • Título:
    Durable mechanical circulatory support in teenagers and adults with congenital heart disease: A systematic review
  • Autor: Steiner, Jill M. ; Krieger, Eric V. ; Stout, Karen K. ; Stempien-Otero, April ; Mahr, Claudius ; Mokadam, Nahush A. ; Hermsen, Joshua L.
  • Assuntos: Mechanical Circulatory Support ; Adult Congenital ; Heart Failure
  • É parte de: International Journal of Cardiology, 15 October 2017, Vol.245, pp.135-140
  • Descrição: BackgroundHeart failure is the leading cause of morbidity and mortality for adults with congenital heart disease (ACHD). Many patients are ineligible for transplantation, and those who are eligible often face long wait times with high wait-list morbidity. Durable mechanical circulatory support (MCS) may be an option for many patients. This systematic review evaluates the published literature on the use of durable MCS in teenagers and adults with congenital heart disease. MethodsA comprehensive search of MEDLINE (PubMed), EMBASE, and the Cochrane Library was performed electronically in July 2015 and updated in March 2016, guided by the Preferred Reporting Items for Systematic Reviews and Meta-Analysis guidelines. ResultsIndividual case reports and several case series identified 66 patients with ACHD treated with durable MCS. More than half were INTERMACS 1 or 2 at the time of implantation. Patients with Fontan repairs were more frequently classified as INTERMACS 1 or 2 (89% compared to 59% or less among other groups). Cases published after 2010 showed a trend toward less severe INTERMACS status, and patients were less likely to have received transplants by the time of reporting (31% compared to 61% prior). Durable MCS was implanted as bridge-to-transplant in 77%. Patients with Fontan repair accounted for 14% of cases. ConclusionReports of durable MCS utilization in patients with ACHD are becoming more frequent and devices are being implanted in more stable patients. Reports are mostly case reports or small case series so reporting bias is likely and prospective protocoled reporting is needed.
  • Idioma: Inglês

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