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Sex Differences in High Sensitivity C-Reactive Protein in Subjects with Risk Factors of Metabolic Syndrome

Garcia, Vinicius Pacheco ; Rocha, Helena Naly Miguens ; Sales, Allan Robson Kluser ; Rocha, Natália Galito ; Nóbrega, Antonio Claudio Lucas Da

Arquivos Brasileiros de Cardiologia, 01 March 2016, Vol.106(3), pp.182-187 [Periódico revisado por pares]

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  • Título:
    Sex Differences in High Sensitivity C-Reactive Protein in Subjects with Risk Factors of Metabolic Syndrome
  • Autor: Garcia, Vinicius Pacheco ; Rocha, Helena Naly Miguens ; Sales, Allan Robson Kluser ; Rocha, Natália Galito ; Nóbrega, Antonio Claudio Lucas Da
  • Assuntos: Cardiac & Cardiovascular Systems ; Síndrome Metabólica ; Fatores de Risco ; Caracteres Sexuais ; Proteína C ; Metabolic Syndrome ; Risk Factors ; Sex Characteristics ; Protein C ; Medicine
  • É parte de: Arquivos Brasileiros de Cardiologia, 01 March 2016, Vol.106(3), pp.182-187
  • Descrição: Abstract Background: Metabolic syndrome (MetS) is associated with a higher risk of all-cause mortality. High-sensitivity C-reactive protein (hsCRP) is a prototypic marker of inflammation usually increased in MetS. Women with MetS-related diseases present higher hsCRP levels than men with MetS-related diseases, suggesting sex differences in inflammatory markers. However, it is unclear whether serum hsCRP levels are already increased in men and/or women with MetS risk factors and without overt diseases or under pharmacological treatment. Objective: To determine the impact of the number of MetS risk factors on serum hsCRP levels in women and men. Methods One hundred and eighteen subjects (70 men and 48 women; 36 ± 1 years) were divided into four groups according to the number of MetS risk factors: healthy group (CT; no risk factors), MetS ≤ 2, MetS = 3, and MetS ≥ 4. Blood was drawn after 12 hours of fasting for measurement of biochemical variables and hsCRP levels, which were determined by immunoturbidimetric assay. Results: The groups with MetS risk factors presented higher serum hsCRP levels when compared with the CT group (p < 0.02). There were no differences in hsCRP levels among groups with MetS risk factors (p > 0.05). The best linear regression model to explain the association between MetS risk factors and hsCRP levels included waist circumference and HDL cholesterol (r = 0.40, p < 0.01). Women with MetS risk factors presented higher hsCRP levels when compared with men (psex < 0.01). Conclusions: Despite the absence of overt diseases and pharmacological treatment, subjects with MetS risk factors already presented increased hsCRP levels, which were significantly higher in women than men at similar conditions.
  • Idioma: Português

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