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Evaluation of CD4+CD25+ T lymphocyte response time kinetics in patients with chronic Chagas disease after in vitro stimulation with recombinant Trypanosoma cruzi antigens

Braz, Suellen Carvalho de Moura ; Lorena, Virginia Maria Barros de ; Melo, Adriene Siqueira ; Cavalcanti, Maria Da Gloria Aureliano Melo ; Gomes, Yara de Miranda

Revista da Sociedade Brasileira de Medicina Tropical, 01 May 2013, Vol.46(3), pp.362-366 [Periódico revisado por pares]

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  • Título:
    Evaluation of CD4+CD25+ T lymphocyte response time kinetics in patients with chronic Chagas disease after in vitro stimulation with recombinant Trypanosoma cruzi antigens
  • Autor: Braz, Suellen Carvalho de Moura ; Lorena, Virginia Maria Barros de ; Melo, Adriene Siqueira ; Cavalcanti, Maria Da Gloria Aureliano Melo ; Gomes, Yara de Miranda
  • Assuntos: Tropical Medicine ; Chronic Chagas Disease ; Recombinant Antigens ; Cd4+Cd25+ T Lymphocytes ; Medicine
  • É parte de: Revista da Sociedade Brasileira de Medicina Tropical, 01 May 2013, Vol.46(3), pp.362-366
  • Descrição: Introduction CD4+CD25+ T lymphocytes have been implicated in the regulation of host inflammatory response against Trypanosoma cruzi, and may be involved in the clinical course of the disease. Methods Peripheral blood mononuclear cells from patients with chronic Chagas disease were cultured in the presence of T. cruzi recombinant antigens and assayed for lymphocytes at distinct time points. Results It was possible to differentiate clinical forms of chronic Chagas disease at days 3 and 5 according to presence of CD4+CD25+ T cells in cell cultures. Conclusions Longer periods of cell culture proved to be potentially valuable for prospective evaluations of CD4+CD25+ T lymphocytes in patients with chronic Chagas disease.
  • Idioma: Português

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