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An immune regulatory CCT repeat containing oligodeoxynucleotide capable of causing hair loss in male mice

Xu, Y ; Liu, J ; Hua, L ; Xiao, Y ; Tian, Y ; Guo, S ; Zhang, X ; He, C ; Wang, L ; Yu, Y

Human & Experimental Toxicology, November 2016, Vol.35(11), pp.1161-1172 [Periódico revisado por pares]

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  • Título:
    An immune regulatory CCT repeat containing oligodeoxynucleotide capable of causing hair loss in male mice
  • Autor: Xu, Y ; Liu, J ; Hua, L ; Xiao, Y ; Tian, Y ; Guo, S ; Zhang, X ; He, C ; Wang, L ; Yu, Y
  • Assuntos: Hair Follicle ; Hair Loss ; Male Mice ; Oligodeoxynucleotide ; Pharmacy, Therapeutics, & Pharmacology ; Public Health
  • É parte de: Human & Experimental Toxicology, November 2016, Vol.35(11), pp.1161-1172
  • Descrição: An oligodeoxynucleotide with CCT repeats (CCT ODN) has been found in our previous study to selectively downregulate Toll-like receptor 7/9 (TLR7/9)-mediated immune responses both in vitro and in vivo. In this study, we unexpectedly found that CCT ODN induced severe patchy hair loss around the mouth in male F1 mice (female Balb/c × male C57BL/6) with lupus-like nephritis induced by injecting allogenic lymphocytes and also in male Balb/c mice, but not in female F1 mice and Balb/c mice and either gender of C57BL/6 mice. Increased infiltration of natural killer group 2, member D (NKG2D+) cells in hair loss skin and upregulated interferon-gamma (IFN-γ) messenger RNA expression in cultured splenocytes were observed in male Balb/c mice. The CCT ODN-conditioned supernatants of cultured mouse splenocytes caused catagen-like changes to hair follicles (HFs). We hypothesized that the CCT ODN could induce patchy hair loss in the male mice with certain genetic traits by mobilizing NKG2D+ cells...
  • Idioma: Inglês

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