skip to main content

Novel contributions on luminescent apatite-based colloids intended for medical imaging

Al-Kattan, Ahmed ; Santran, Veronique ; Dufour, Pascal ; Dexpert-Ghys, Jeannette ; Drouet, Christophe

Journal of Biomaterials Applications, January 2014, Vol.28(5), pp.697-707 [Periódico revisado por pares]

Texto completo disponível

Citações Citado por
  • Título:
    Novel contributions on luminescent apatite-based colloids intended for medical imaging
  • Autor: Al-Kattan, Ahmed ; Santran, Veronique ; Dufour, Pascal ; Dexpert-Ghys, Jeannette ; Drouet, Christophe
  • Assuntos: Bionanotechnology ; Materials-Cells Interactions ; Colloids ; Hybrid Materials ; Luminescence ; Cancer ; Biomimetic Apatites ; Hydroxyapatite ; Engineering
  • É parte de: Journal of Biomaterials Applications, January 2014, Vol.28(5), pp.697-707
  • Descrição: The setup of colloidal hybrid nanosystems based on biomimetic calcium phosphate apatites doped with europium ions has recently raised great interest in the pharmacological community, especially due to their bio-inspired character. This is especially relevant in relation with medical imaging for cancer diagnosis. Questions however remain in relation to a number of applicability aspects, some of which have been examined in this contribution. In a first part of this work, we explored further the luminescence properties of such colloidal nanoparticles. We pointed out, upon excitation of europium, the existence of some non-radiative de-excitation via the vibration of O-H oscillators located at the vicinity of the Eu(3+) luminescent centers. The replacement of Eu(3+) by Tb(3+) ions, less prone to non-radiative de-excitation, was then tested in a preliminary way and can be seen as a promising alternative. In a second part of this work, we inspected the possibility to store these colloids in a dry state while retaining a re-suspension ability preserving the nanometer size of the initial nanoparticles, and we propose a functional protocol involving the addition of glucose prior to freeze-drying. We finally showed for the first time, based on titrations of intracellular Ca(2+) and Eu(3+) ions, that folic acid-functionalized biomimetic apatite nanoparticles were able to target cancer cells that overexpress folate receptors on their membrane, which we point out here in the case of T-47-D breast carcinoma cells, as opposed to ZR-75-1 cells that do not express folate receptors. This contribution thus opens new exciting perspectives in the field of targeted cancer diagnosis, thus confirming the promise of biomimetic apatites-based colloidal formulations.
  • Idioma: Inglês

Buscando em bases de dados remotas. Favor aguardar.