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Gender differences in metformin effect on aging, life span and spontaneous tumorigenesis in 129/Sv mice

Anisimov, Vladimir N ; Piskunova, Tatiana S ; Popovich, Irina G ; Zabezhinski, Mark A ; Tyndyk, Margarita L ; Egormin, Peter A ; Yurova, Maria N ; Rosenfeld, Svetlana V ; Semenchenko, Anna V ; Kovalenko, Irina G ; Poroshina, Tatiana E ; Berstein, Lev M

Aging (Albany NY), 2010, Vol.2(12), p.945-958 [Periódico revisado por pares]

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  • Título:
    Gender differences in metformin effect on aging, life span and spontaneous tumorigenesis in 129/Sv mice
  • Autor: Anisimov, Vladimir N ; Piskunova, Tatiana S ; Popovich, Irina G ; Zabezhinski, Mark A ; Tyndyk, Margarita L ; Egormin, Peter A ; Yurova, Maria N ; Rosenfeld, Svetlana V ; Semenchenko, Anna V ; Kovalenko, Irina G ; Poroshina, Tatiana E ; Berstein, Lev M
  • Assuntos: Research Paper ; Metformin ; Biomarkers Of Aging ; Life Extension ; Carcinogenesis ; Mice
  • É parte de: Aging (Albany NY), 2010, Vol.2(12), p.945-958
  • Descrição: Studies in mammals have led to the suggestion that hyperglycemia and hyperinsulinemia are important factors both in aging and in the development of cancer. It is possible that the life-prolonging effects of calorie restriction are due to decreasing IGF-1 levels. A search of pharmacological modulators of insulin/IGF-1 signaling pathway (which mimetic effects of life span extending mutations or calorie restriction) could be a perspective direction in regulation of longevity. Antidiabetic biguanides are most promising among them. The chronic treatment of inbred 129/Sv mice with metformin (100 mg/kg in drinking water) slightly modified the food consumption but failed to influence the dynamics of body weight, decreased by 13.4% the mean life span of male mice and slightly increased the mean life span of female mice (by 4.4%). The treatment with metformin failed influence spontaneous tumor incidence in male 129/Sv mice, decreased by 3.5 times the incidence of malignant neoplasms in female mice while somewhat stimulated formation of benign vascular tumors in the latter.

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