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Histopathological features of papillary thyroid carcinomas detected during four screening examinations of a Ukrainian-American cohort

Tetiana I Bogdanova ; Liudmyla Yu Zurnadzhy ; Yuri E Nikiforov ; Rebecca J Leeman-Neill ; Mykola D Tronko ; Stephen Chanock ; Kiyohiko Mabuchi ; Ilya A Likhtarov ; Leonila M Kovgan ; Vladimir Drozdovitch ; Mark P Little ; Maureen Hatch ; Lydia B Zablotska ; Viktor M Shpak ; Robert J Mcconnell ; Alina V Brenner

British Journal of Cancer, 2015, Vol.113(11), p.1556 [Periódico revisado por pares]

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  • Título:
    Histopathological features of papillary thyroid carcinomas detected during four screening examinations of a Ukrainian-American cohort
  • Autor: Tetiana I Bogdanova ; Liudmyla Yu Zurnadzhy ; Yuri E Nikiforov ; Rebecca J Leeman-Neill ; Mykola D Tronko ; Stephen Chanock ; Kiyohiko Mabuchi ; Ilya A Likhtarov ; Leonila M Kovgan ; Vladimir Drozdovitch ; Mark P Little ; Maureen Hatch ; Lydia B Zablotska ; Viktor M Shpak ; Robert J Mcconnell ; Alina V Brenner
  • Assuntos: Clinical Study ; Thyroid Cancer ; Papillary Thyroid Carcinoma ; Radiation ; Iodine-131 ; Pathology ; Chernobyl ; Chornobyl
  • É parte de: British Journal of Cancer, 2015, Vol.113(11), p.1556
  • Descrição: Background: There are limited data on the histopathology of papillary thyroid carcinomas (PTCs) diagnosed in irradiated populations. We evaluated the associations between iodine-131 dose and the histopathological characteristics of post-Chernobyl PTCs, the changes in these characteristics over time, and their associations with selected somatic mutations. Methods: This study included 115 PTCs diagnosed in a Ukrainian-American cohort ( n =13 243) during prescreening and four successive thyroid screenings. Of these PTCs, 65 were subjected to somatic mutation profiling. All individuals were <18 years at the time of the Chernobyl accident and had direct thyroid radioactivity measurements. Statistical analyses included multivariate linear and logistic regression. Results: We identified a borderline significant linear-quadratic association ( P =0.063) between iodine-131 dose and overall tumour invasiveness (presence of extrathyroidal extension, lymphatic/vascular invasion, and regional or distant metastases). Irrespective of dose, tumours with chromosomal rearrangements were more likely to have lymphatic/vascular invasion than tumours without chromosomal rearrangements ( P =0.020) or tumours with BRAF or RAS point mutations ( P =0.008). Controlling for age, there were significant time trends in decreasing tumour size ( P <0.001), the extent of lymphatic/vascular invasion ( P =0.005), and overall invasiveness ( P =0.026). Conclusions: We determined that the invasive properties of PTCs that develop in iodine-131-exposed children may be associated with radiation dose. In addition, based on a subset of cases, tumours with chromosomal rearrangements appear to have a more invasive phenotype. The increase in small, less invasive PTCs over time is a consequence of repeated screening examinations.

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