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Variability of Leishmania (Leishmania) infantum among stocks from immunocompromised, immunocompetent patients and dogs in Spain

Jiménez, M ; Ferrer-Dufol, M ; Cañavate, C ; Gutiérrez-Solar, B ; Molina, R ; Laguna, F ; López-Vélez, R ; Cercenado, E ; Daudén, E ; Blázquez, J

FEMS microbiology letters, 01 September 1995, Vol.131(2), pp.197-204 [Periódico revisado por pares]

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  • Título:
    Variability of Leishmania (Leishmania) infantum among stocks from immunocompromised, immunocompetent patients and dogs in Spain
  • Autor: Jiménez, M ; Ferrer-Dufol, M ; Cañavate, C ; Gutiérrez-Solar, B ; Molina, R ; Laguna, F ; López-Vélez, R ; Cercenado, E ; Daudén, E ; Blázquez, J
  • Assuntos: Genetic Variation ; Dogs -- Parasitology ; Leishmania Infantum -- Genetics
  • É parte de: FEMS microbiology letters, 01 September 1995, Vol.131(2), pp.197-204
  • Descrição: Leishmania (Leishmania) infantum is the causative agent of both the cutaneous and visceral forms of leishmaniasis in southwest Europe; the dog is the main reservoir. In order to identify the L. (L.) infantum zymodemes present in Spain, a total number of 85 Leishmania stocks isolated from dogs (31), HIV-positive patients (46) with visceral or cutaneous leishmaniasis, a patient with visceral leishmaniasis complicating renal transplantation (1) and immunocompetent patients (7) with visceral or cutaneous leishmaniasis, have been characterized by isoenzyme typing. All canine stocks were MON-1, which is the most widespread zymodeme in the Mediterranean area. In immunocompetent patients three zymodemes were found: MON-1 (2), MON-24 (2) and MON-34 (3). Nine different zymodemes were obtained in stocks from HIV co-infected patients, indicating a higher variability of L. (L.) infantum amongst them: MON-1 (in 21 stocks), MON-24 (7), MON-28 (1), MON-29 (3), MON-33 (7), MON-34 (1) and MON-183 (4). Two...
  • Idioma: Inglês

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