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Toxicologic studies of four fluorescent whitening agents

Keplinger, M L ; Fancher, O E ; Lyman, F L ; Calandra, J C

Toxicology and applied pharmacology, March 1974, Vol.27(3), pp.494-506 [Periódico revisado por pares]

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  • Título:
    Toxicologic studies of four fluorescent whitening agents
  • Autor: Keplinger, M L ; Fancher, O E ; Lyman, F L ; Calandra, J C
  • Assuntos: Fluorescent Dyes -- Toxicity
  • É parte de: Toxicology and applied pharmacology, March 1974, Vol.27(3), pp.494-506
  • Descrição: Studies have been conducted to define the toxicologic properties of sodium 2-(4-styryl-3-sulfophenyl)-2 H-naphtho-[1,2 d]triazole (I), disodium 4,4′-bis[(4-anilino-6-morpholino-1,3,5-triazin-2-yl)amino]stilbene-2,2′-disulfonate (II), disodium 4,4′-bis{[4-anilino-6-6-( N-methyl-2-hydroxyethylamino)-1,3,5-triazin-2-yl]amino}stilbene-2,2′-disulfonate (III) and disodium 4,4′-bis(2-sulfostyryl)biphenyl (IV). The following studies were performed on all the above materials: acute oral LD50, acute eye irritation, acute dust inhalation, acute fish toxicity, dominant lethal mutagenicity, teratogenicity, 90-day subacute oral toxicity in rats and dogs, and repeated insult patch tests in humans. Under the conditions of these studies the compounds were of low toxicity and were neither teratogenic nor mutagenic. Dose-related effects ranging from mild gastritis at 400 ppm to debilitation and peritonitis at 2000 ppm were observed in the 90-day dog feeding study with unbuffered compound...
  • Idioma: Inglês

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