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How Ocular Surface Microbiota Debuts in Type 2 Diabetes Mellitus

Li, Siqi ; Yi, Guoguo ; Peng, Hui ; Li, Zhenhao ; Chen, Shuze ; Zhong, Huimin ; Chen, Yifan ; Wang, Zhoucheng ; Deng, Qixin ; Fu, Min

Frontiers in cellular and infection microbiology, 2019, Vol.9, pp.202 [Periódico revisado por pares]

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  • Título:
    How Ocular Surface Microbiota Debuts in Type 2 Diabetes Mellitus
  • Autor: Li, Siqi ; Yi, Guoguo ; Peng, Hui ; Li, Zhenhao ; Chen, Shuze ; Zhong, Huimin ; Chen, Yifan ; Wang, Zhoucheng ; Deng, Qixin ; Fu, Min
  • Assuntos: Diabetes Mellitus ; Flora ; Infection ; Microbiota ; Ocular Surface
  • É parte de: Frontiers in cellular and infection microbiology, 2019, Vol.9, pp.202
  • Descrição: High glucose represents a good environment for bacterial growth on the skin, on the ocular surface (OS) and in the tears of type 2 diabetes mellitus (T2DM) patients, affecting the conjunctival bacterial community. This study aimed to investigate the OS bacterial flora of T2DM patients and healthy subjects using 16S rRNA sequencing-based bacterial identification. Among 23 healthy subjects (CON) and 31 T2DM patients, 54 eyes were examined to investigate the OS bacterial community. Factors potentially affecting the microbial growth were controlled. Results showed the OS microbiota presented higher diversity in the T2DM group than in the CON group. Bioinformatic analysis showed a lower abundance of and a higher abundance of at the phyla level as well as a significantly increased abundance of and at the genus level in the T2DM group. The difference in OS microbiota at taxonomic level was associated with Ocular Surface Disease Index and course of T2DM. These findings indicate the OS flora...
  • Idioma: Inglês

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