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Fluorouracil-Loaded Gold Nanoparticles for the Treatment of Skin Cancer: Development, in Vitro Characterization, and in Vivo Evaluation in a Mouse Skin Cancer Xenograft Model

Safwat, Mohamed A ; Soliman, Ghareb M ; Sayed, Douaa ; Attia, Mohamed A

Molecular pharmaceutics, 04 June 2018, Vol.15(6), pp.2194-2205 [Periódico revisado por pares]

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  • Título:
    Fluorouracil-Loaded Gold Nanoparticles for the Treatment of Skin Cancer: Development, in Vitro Characterization, and in Vivo Evaluation in a Mouse Skin Cancer Xenograft Model
  • Autor: Safwat, Mohamed A ; Soliman, Ghareb M ; Sayed, Douaa ; Attia, Mohamed A
  • Assuntos: 5-Fluorouracil ; Cetyltrimethylammonium Bromide ; Gold Nanoparticles ; Skin Cancer
  • É parte de: Molecular pharmaceutics, 04 June 2018, Vol.15(6), pp.2194-2205
  • Descrição: Fluorouracil (5-FU) is an antimetabolite drug used in the treatment of various malignancies, such as colon and skin cancers. However, its systemic administration results in severe side effects. Topical 5-FU delivery for the treatment of skin cancer could circumvent these shortcomings, but it is limited by the drug poor permeability through the skin. To enhance 5-FU efficacy against skin cancer and reduce its systemic side effects, it was loaded into a gold nanoparticle (GNP)-based topical delivery system. 5-FU was loaded onto GNPs capped with CTAB through ionic interactions between 5-FU and CTAB. GNPs were prepared at different 5-FU/CTAB molar ratios and evaluated using different techniques. GNP stability and drug release were studied as a function of salt concentration and solution pH. Optimum 5-FU/CTAB-GNPs were incorporated into gel and cream bases, and their ex vivo permeability was evaluated in mice dorsal skin. The in vivo anticancer efficacy of the same preparations was evaluated...
  • Idioma: Inglês

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