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Newly identified biomarkers for detecting circulating tumor cells in lung adenocarcinoma

Man, Yingchun ; Cao, Jingyan ; Jin, Shi ; Xu, Gang ; Pan, Bo ; Shang, Lihua ; Che, Dehai ; Yu, Qin ; Yu, Yan

The Tohoku journal of experimental medicine, September 2014, Vol.234(1), pp.29-40 [Periódico revisado por pares]

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  • Título:
    Newly identified biomarkers for detecting circulating tumor cells in lung adenocarcinoma
  • Autor: Man, Yingchun ; Cao, Jingyan ; Jin, Shi ; Xu, Gang ; Pan, Bo ; Shang, Lihua ; Che, Dehai ; Yu, Qin ; Yu, Yan
  • Assuntos: Adenocarcinoma -- Diagnosis ; Biomarkers, Tumor -- Metabolism ; Lung Neoplasms -- Diagnosis ; Neoplastic Cells, Circulating -- Chemistry ; RNA, Messenger -- Metabolism
  • É parte de: The Tohoku journal of experimental medicine, September 2014, Vol.234(1), pp.29-40
  • Descrição: Circulating tumor cells (CTCs) have been implicated in cancer prognosis and follow up. Detection of CTCs was considered significant in cancer evaluation. However, due to the heterogeneity and rareness of CTCs, detecting them with a single maker is usually challenged with low specificity and sensitivity. Previous studies concerning CTCs detection in lung cancer mainly focused on non-small cell lung carcinoma. Currently, there is no report yet describing the CTC detection with multiple markers in lung adenocarcinoma. In this study, by employing quantitative real-time PCR, we identified four candidate genes (mRNA) that were significantly elevated in peripheral blood mononuclear cells and biopsy tissue samples from patients with lung adenocarcinoma: cytokeratin 7 (CK7), Ca(2+)-activated chloride channel-2 (CLCA2), hyaluronan-mediated motility receptor (HMMR), and human telomerase catalytic subunit (hTERT). Then, the four markers were used for CTC detection; namely, positive detection was defined...
  • Idioma: Inglês

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