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Control of axon-axon attraction by Semaphorin reverse signaling

Hsieh, Hsiao-Han ; Chang, Wen-Tzu ; Yu, Li ; Rao, Yong

Proceedings of the National Academy of Sciences of the United States of America, 05 August 2014, Vol.111(31), pp.11383-8 [Periódico revisado por pares]

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  • Título:
    Control of axon-axon attraction by Semaphorin reverse signaling
  • Autor: Hsieh, Hsiao-Han ; Chang, Wen-Tzu ; Yu, Li ; Rao, Yong
  • Assuntos: Signal Transduction ; Axons -- Metabolism ; Drosophila Melanogaster -- Metabolism ; Semaphorins -- Metabolism
  • É parte de: Proceedings of the National Academy of Sciences of the United States of America, 05 August 2014, Vol.111(31), pp.11383-8
  • Descrição: Semaphorin family proteins are well-known axon guidance ligands. Recent studies indicate that certain transmembrane Semaphorins can also function as guidance receptors to mediate axon-axon attraction or repulsion. The mechanisms by which Semaphorin reverse signaling modulates axon-surface affinity, however, remain unknown. In this study, we reveal a novel mechanism underlying upregulation of axon-axon attraction by Semaphorin-1a (Sema1a) reverse signaling in the developing Drosophila visual system. Sema1a promotes the phosphorylation and activation of Moesin (Moe), a member of the ezrin/radixin/moesin family of proteins, and downregulates the level of active Rho1 in photoreceptor axons. We propose that Sema1a reverse signaling activates Moe, which in turn upregulates Fas2-mediated axon-axon attraction by inhibiting Rho1.
  • Idioma: Inglês

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