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Variation in genes involved in epigenetic processes offers insights into tropically adapted cattle diversity

Porto-Neto, Laercio R ; Fortes, Marina R S ; Mcwilliam, Sean M ; Lehnert, Sigrid A ; Reverter, Antonio

Frontiers in genetics, 2014, Vol.5, pp.89 [Periódico revisado por pares]

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  • Título:
    Variation in genes involved in epigenetic processes offers insights into tropically adapted cattle diversity
  • Autor: Porto-Neto, Laercio R ; Fortes, Marina R S ; Mcwilliam, Sean M ; Lehnert, Sigrid A ; Reverter, Antonio
  • Assuntos: Bovine Species ; Cattle Diversity ; Epigenetics ; High-Density Genotypes ; Polymorphisms
  • É parte de: Frontiers in genetics, 2014, Vol.5, pp.89
  • Descrição: We evaluated the relevance of the BovineHD Illumina SNP chip with respect to genes involved in epigenetic processes. Genotypes for 729,068 SNP on two tropical cattle breeds of Australia were used: Brahman (n = 2112) and Tropical Composite (n = 2550). We used data mining approaches to compile a list of bovine protein-coding genes involved in epigenetic processes. These genes represent 9 functional categories that contain between one (histone demethylases) and 99 (chromatin remodeling factors) genes. A total of 3091 SNP mapped to positions within 3000 bp of the 193 coding regions of those genes, including 113 SNP in transcribed regions, 2738 in intronic regions and 240 in up- or down-stream regions. For all these SNP categories, we observed differences in the allelic frequencies between Brahman and Tropical Composite cattle. These differences were larger than those observed for the entire set of 729,068 SNP (P = 1.79 x 10(-5)). A multidimensional scaling analysis using only the 113 SNP in...
  • Idioma: Inglês

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