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Antifungal activity of phlorotannins against dermatophytes and yeasts: approaches to the mechanism of action and influence on Candida albicans virulence factor

Lopes, Graciliana ; Pinto, Eugénia ; Andrade, Paula B ; Valentão, Patrícia

PloS one, 2013, Vol.8(8), pp.e72203 [Periódico revisado por pares]

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  • Título:
    Antifungal activity of phlorotannins against dermatophytes and yeasts: approaches to the mechanism of action and influence on Candida albicans virulence factor
  • Autor: Lopes, Graciliana ; Pinto, Eugénia ; Andrade, Paula B ; Valentão, Patrícia
  • Assuntos: Antifungal Agents -- Pharmacology ; Arthrodermataceae -- Drug Effects ; Tannins -- Pharmacology ; Yeasts -- Drug Effects
  • É parte de: PloS one, 2013, Vol.8(8), pp.e72203
  • Descrição: In the last few decades, fungal infections, particularly nosocomial, increased all around the world. This increment stimulated the search for new antifungal agents, especially those derived from nature. Among natural products, those from marine sources have gained prominence in the last years. Purified phlorotannins extracts from three brown seaweeds (Cystoseira nodicaulis (Withering) M. Roberts, Cystoseira usneoides (Linnaeus) M. Roberts and Fucus spiralis Linnaeus) were screened for their antifungal activity against human pathogenic yeast and filamentous fungi. The purified phlorotannins extracts from the studied seaweeds displayed fungistatic and fungicidal activity against yeast and dermatophytes, respectively, pointing to their interest as anti-dermatophyte agent. C. albicans ATCC 10231 was the most susceptible among yeast, while Epidermophyton floccosum and Trichophyton rubrum were the most susceptible among dermatophytes. Since the antifungal mechanism constitutes an important strategy...
  • Idioma: Inglês

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