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Time course of urothelial changes in rats and mice orally administered arsenite

Arnold, Lora L ; Suzuki, Shugo ; Yokohira, Masanao ; Kakiuchi-Kiyota, Satoko ; Pennington, Karen L ; Cohen, Samuel M

Toxicologic pathology, July 2014, Vol.42(5), pp.855-62 [Periódico revisado por pares]

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  • Título:
    Time course of urothelial changes in rats and mice orally administered arsenite
  • Autor: Arnold, Lora L ; Suzuki, Shugo ; Yokohira, Masanao ; Kakiuchi-Kiyota, Satoko ; Pennington, Karen L ; Cohen, Samuel M
  • Assuntos: Arsenic ; Cell Proliferation. ; Cytotoxicity ; Hyperplasia ; Urinary Bladder ; Arsenites -- Administration & Dosage ; Urothelium -- Drug Effects
  • É parte de: Toxicologic pathology, July 2014, Vol.42(5), pp.855-62
  • Descrição: Inorganic arsenic (arsenite and arsenate) at high exposures is a known human carcinogen, inducing tumors of the urinary bladder, skin, and lungs. In two experiments, we examined the urothelial proliferative effects of treatment with 173 ppm sodium arsenite (100 ppm arsenic) in the drinking water for 6 and 24 hr, and 3, 7, and 14 days in female F344 rats and 43.3 ppm sodium arsenite (25 ppm arsenic) in female C57BL/6 wild-type and arsenic (+3 oxidation state) methyltransferase knockout (As3mt KO) mice that are unable to methylate arsenicals. In the rat and both mouse genotypes, scanning electron microscopy showed cytotoxic urothelial changes as early as 6 hr after the start of arsenic exposure. The severity of As(III)-induced cytotoxic urothelial changes increased over time in the rat and in the As3mt KO mouse. Light microscopy showed an increase in urothelial hyperplasia in the rat. No significant increases in bromodeoxyuridine-labeling index were observed. The data support the hypothesis...
  • Idioma: Inglês

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