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Efficacy of the stannous ion and a biopolymer in toothpastes on enamel erosion/abrasion

Ganss, C ; Von Hinckeldey, J ; Tolle, A ; Schulze, K ; Klimek, J ; Schlueter, N

Journal of dentistry, December 2012, Vol.40(12), pp.1036-43 [Periódico revisado por pares]

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  • Título:
    Efficacy of the stannous ion and a biopolymer in toothpastes on enamel erosion/abrasion
  • Autor: Ganss, C ; Von Hinckeldey, J ; Tolle, A ; Schulze, K ; Klimek, J ; Schlueter, N
  • Assuntos: Chitosan -- Pharmacology ; Dental Enamel -- Drug Effects ; Tin Compounds -- Pharmacology ; Tooth Abrasion -- Pathology ; Tooth Erosion -- Pathology ; Toothpastes -- Pharmacology
  • É parte de: Journal of dentistry, December 2012, Vol.40(12), pp.1036-43
  • Descrição: Sn(2+) has promising erosion-inhibiting properties in solutions, but little is known about respective effects in toothpastes. In addition, biopolymers might have protecting potential. Aim of this study was to investigate the effects of Sn(2+) in toothpastes and of a biopolymer (chitosan) added to a Sn(2+) formulation on erosion/abrasion. Enamel samples were subjected to cyclic erosion procedures (10 days; 0.50% citric acid, pH 2.5; 6× 2 min/day), and brushing (2× 15s/day, load 200 g) during immersion in slurries (2 min). The toothpastes were NaF formulations (NaF/1, NaF/2, NaF/3) and Sn(2+) formulations (NaF/SnCl(2), AmF/SnF(2), AmF/NaF/SnCl(2)) and AmF/NaF/SnCl(2)+0.5% chitosan. Declared concentrations of active ingredients in toothpastes were 1400-1450 μg/g F(-) and 3280-3500 μg/g Sn(2+). Negative controls were erosion only and placebo, positive control was a SnF(2) gel. Tissue loss was quantified profilometrically, Sn on enamel surfaces was measured by energy dispersive X-ray spectroscopy. Loss values (μm) for erosion only and placebo were 14.4 ± 4.5 and 20.2 ± 3.8, respectively, and 4.6 ± 1.9 for the positive control (p ≤ 0.001 each compared to erosion only). The other loss values were: NaF/1 16.5 ± 3.0, NaF/2 14.0 ± 2.7, NaF/3 12.6 ± 3.9, NaF/SnCl(2) 14.7 ± 5.1, AmF/SnF(2) 13.5 ± 4.8, AmF/NaF/SnCl(2) 12.4 ± 4.2, AmF/NaF/SnCl(2)+chitosan 6.6 ± 3.5 (except NaF/1 all p ≤ 0.01 compared to placebo). AmF/NaF/SnCl(2)/chitosan was more effective than all other toothpastes (p ≤ 0.01 each). Sn on the enamel surface ranged between 1.3 ± 0.3 and 2.8 ± 0.04 wt.% with no obvious relationship with efficacy.
  • Idioma: Inglês

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