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Anti-tumor effect of lentivirus-mediated gene transfer of alphastatin on human glioma

Guo, Shi-Wen ; Che, Hong-Min ; Li, Wen-Zhi

Cancer science, May 2011, Vol.102(5), pp.1038-44 [Periódico revisado por pares]

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  • Título:
    Anti-tumor effect of lentivirus-mediated gene transfer of alphastatin on human glioma
  • Autor: Guo, Shi-Wen ; Che, Hong-Min ; Li, Wen-Zhi
  • Assuntos: Fibrinogen -- Genetics ; Genetic Therapy -- Methods ; Glioma -- Therapy ; Neovascularization, Pathologic -- Therapy
  • É parte de: Cancer science, May 2011, Vol.102(5), pp.1038-44
  • Descrição: Alphastatin, an endogenous angiogenesis inhibitor, has recently been used as an anticancer agent in several tumor models. This study was to investigate whether local sustained long-term expression of alphastatin could serve to diminish tumor growth of a human xenograft glioma model. We found that the recombinant alphastatin lentiviruses were able to stably infect HUVECs, and infected HUVECs could sustainably secrete alphastatin, which exhibited potent inhibitory effects on HUVECs migration, differentiation but not proliferation induced by vascular endothelial growth factor (VEGF) or basic fibroblast growth factor(bFGF). And the expression of secreted protein alphastatin markedly decreased tumor vascularization and inhibited tumor growth. Additionally, alphastatin inhibited VEGF- or bFGF-induced initial stage of angiogenesis by reducing JNk and ERK phosphorylation in vitro. Taken together, these data demonstrate that secreted protein alphastatin inhibits VEGF- or bFGF-induced angiogenesis...
  • Idioma: Inglês

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