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The brain-derived neurotrophic factor Val66Met polymorphism is associated with reduced functional magnetic resonance imaging activity in the hippocampus and increased use of caudate nucleus-dependent strategies in a human virtual navigation task

Banner, Harrison ; Bhat, Venkataramana ; Etchamendy, Nicole ; Joober, Ridha ; Bohbot, Véronique D

The European journal of neuroscience, March 2011, Vol.33(5), pp.968-77 [Periódico revisado por pares]

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  • Título:
    The brain-derived neurotrophic factor Val66Met polymorphism is associated with reduced functional magnetic resonance imaging activity in the hippocampus and increased use of caudate nucleus-dependent strategies in a human virtual navigation task
  • Autor: Banner, Harrison ; Bhat, Venkataramana ; Etchamendy, Nicole ; Joober, Ridha ; Bohbot, Véronique D
  • Assuntos: Polymorphism, Genetic ; Brain-Derived Neurotrophic Factor -- Genetics ; Caudate Nucleus -- Physiology ; Hippocampus -- Physiology ; Magnetic Resonance Imaging -- Methods ; Psychomotor Performance -- Physiology ; Spatial Behavior -- Physiology
  • É parte de: The European journal of neuroscience, March 2011, Vol.33(5), pp.968-77
  • Descrição: Multiple memory systems are involved in parallel processing of spatial information during navigation. A series of studies have distinguished between hippocampus-dependent 'spatial' navigation, which relies on knowledge of the relationship between landmarks in one's environment to build a cognitive map, and habit-based 'response' learning, which requires the memorization of a series of actions and is mediated by the caudate nucleus. Studies have demonstrated that people spontaneously use one of these two alternative navigational strategies with almost equal frequency to solve a given navigation task, and that strategy correlates with functional magnetic resonance imaging (fMRI) activity and grey matter density. Although there is evidence for experience modulating grey matter in the hippocampus, genetic contributions may also play an important role in the hippocampus and caudate nucleus. Recently, the Val66Met polymorphism of the brain-derived neurotrophic factor (BDNF) gene has emerged as...
  • Idioma: Inglês

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