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An NADPH-dependent genetic switch regulates plant infection by the rice blast fungus

Wilson, Richard A ; Gibson, Robert P ; Quispe, Cristian F ; Littlechild, Jennifer A ; Talbot, Nicholas J

Proceedings of the National Academy of Sciences of the United States of America, 14 December 2010, Vol.107(50), pp.21902-7 [Periódico revisado por pares]

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  • Título:
    An NADPH-dependent genetic switch regulates plant infection by the rice blast fungus
  • Autor: Wilson, Richard A ; Gibson, Robert P ; Quispe, Cristian F ; Littlechild, Jennifer A ; Talbot, Nicholas J
  • Assuntos: Gene Expression Regulation, Fungal ; Magnaporthe -- Genetics ; Nadp -- Metabolism ; Oryza -- Microbiology ; Plant Diseases -- Microbiology
  • É parte de: Proceedings of the National Academy of Sciences of the United States of America, 14 December 2010, Vol.107(50), pp.21902-7
  • Descrição: To cause rice blast disease, the fungus Magnaporthe oryzae breaches the tough outer cuticle of the rice leaf by using specialized infection structures called appressoria. These cells allow the fungus to invade the host plant and proliferate rapidly within leaf tissue. Here, we show that a unique NADPH-dependent genetic switch regulates plant infection in response to the changing nutritional and redox conditions encountered by the pathogen. The biosynthetic enzyme trehalose-6-phosphate synthase (Tps1) integrates control of glucose-6-phosphate metabolism and nitrogen source utilization by regulating the oxidative pentose phosphate pathway, the generation of NADPH, and the activity of nitrate reductase. We report that Tps1 directly binds to NADPH and, thereby, regulates a set of related transcriptional corepressors, comprising three proteins, Nmr1, Nmr2, and Nmr3, which can each bind NADP. Targeted deletion of any of the Nmr-encoding genes partially suppresses the nonpathogenic phenotype of...
  • Idioma: Inglês

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