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Lethal necrotizing pneumonia caused by an ST398 Staphylococcus aureus strain

Rasigade, Jean-Philippe ; Laurent, Frederiç ; Hubert, Philippe ; Vandenesch, Francois ; Etienne, Jerome

Emerging infectious diseases, August 2010, Vol.16(8), pp.1330 [Periódico revisado por pares]

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  • Título:
    Lethal necrotizing pneumonia caused by an ST398 Staphylococcus aureus strain
  • Autor: Rasigade, Jean-Philippe ; Laurent, Frederiç ; Hubert, Philippe ; Vandenesch, Francois ; Etienne, Jerome
  • Assuntos: Pneumonia -- Microbiology ; Staphylococcal Infections -- Microbiology ; Staphylococcus Aureus -- Isolation & Purification
  • É parte de: Emerging infectious diseases, August 2010, Vol.16(8), pp.1330
  • Descrição: To the Editor: Several recent studies have shown massive colonization of livestock (especially pigs) and livestock workers by methicillin-resistant Staphylococcus aureus (MRSA) in western Europe, Canada, and the United States (1,2). Livestock MRSA isolates belong almost exclusively to a single sequence type, ST398. Evidence of zoonotic and interhuman transmission of methicillin-resistant and methicillin-susceptible variants of this hitherto unusual sequence type was recently reported (1,3). S. aureus ST398 infections in humans with or without a history of contact with livestock include bacteremia, endocarditis, ventilator-associated pneumonia, and wound infections, none of which involve the expression of specific toxins. Indeed, ST398 isolates are negative for all major virulence factors, with the exception of some rare isolates that harbor the genes that encode the Panton-Valentine leukocidin (PVL) (1), a toxin that is usually associated with community-acquired MRSA (4). We report a case of lethal necrotizing pneumonia caused by a PVL-positive methicillin-susceptible ST398 S. aureus isolate.
  • Idioma: Inglês

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