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Polymorphisms in the bovine lactoferrin promoter are associated with reproductive performance and somatic cell count

O'Halloran, F ; Berry, D P ; Bahar, B ; Howard, D J ; Sweeney, T ; Giblin, L

Journal of dairy science, March 2010, Vol.93(3), pp.1253-9 [Periódico revisado por pares]

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  • Título:
    Polymorphisms in the bovine lactoferrin promoter are associated with reproductive performance and somatic cell count
  • Autor: O'Halloran, F ; Berry, D P ; Bahar, B ; Howard, D J ; Sweeney, T ; Giblin, L
  • Assuntos: Cattle -- Genetics ; Lactoferrin -- Genetics ; Milk -- Cytology ; Polymorphism, Single Nucleotide -- Genetics ; Promoter Regions, Genetic -- Genetics ; Reproduction -- Genetics
  • É parte de: Journal of dairy science, March 2010, Vol.93(3), pp.1253-9
  • Descrição: Lactoferrin plays an important role in the innate immune system, with well-characterized antibacterial, antiviral, and immune modulatory properties. The objective of this study was to determine the allele and haplotype frequency of polymorphisms at positions -586, -190, and -28 of the bovine lactoferrin promoter in Holstein-Friesians and to quantify their association with performance using phenotypic data on progeny from 848 sires. Associations between genotypes and performance were quantified using weighted mixed models with genotyped individuals included as a random effect, and average expected relationships among individuals accounted for through a numerator relationship matrix. The dependent variables were daughter yield deviation for production traits and deregressed predicted transmitting ability for calving interval and functional survival. The C to T polymorphism at -586, which distorts a putative activating protein 2 (AP-2) binding site, was associated with a shorter calving interval...
  • Idioma: Inglês

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