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Mobilization of peripheral blood stem cells for autologous transplant in non-Hodgkin's lymphoma and multiple myeloma patients by plerixafor and G-CSF and detection of tumor cell mobilization by PCR in multiple myeloma patients

Fruehauf, S ; Ehninger, G ; Hübel, K ; Topaly, J ; Goldschmidt, H ; Ho, A D ; Müller, S ; Moos, M ; Badel, K ; Calandra, G

Bone marrow transplantation, February 2010, Vol.45(2), pp.269-75 [Periódico revisado por pares]

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  • Título:
    Mobilization of peripheral blood stem cells for autologous transplant in non-Hodgkin's lymphoma and multiple myeloma patients by plerixafor and G-CSF and detection of tumor cell mobilization by PCR in multiple myeloma patients
  • Autor: Fruehauf, S ; Ehninger, G ; Hübel, K ; Topaly, J ; Goldschmidt, H ; Ho, A D ; Müller, S ; Moos, M ; Badel, K ; Calandra, G
  • Assuntos: Hematopoietic Stem Cell Mobilization -- Methods ; Heterocyclic Compounds -- Therapeutic Use ; Lymphoma, Non-Hodgkin -- Therapy ; Multiple Myeloma -- Therapy
  • É parte de: Bone marrow transplantation, February 2010, Vol.45(2), pp.269-75
  • Descrição: This report describes the first investigational use of plerixafor in Europe and the determination of tumor cell mobilization by polymerase chain-reaction after plerixafor treatment in a subset of patients with multiple myeloma (MM). Thirty-five patients (31 MM and 4 NHL) received granulocyte colony-stimulating factor (G-CSF) (10 microg/kg) each morning for 4 days. Starting the evening of Day 4, patients recieved plerixafor 0.24 mg/kg. Apheresis was initiated 10-11 h later, in the morning of Day 5. This regimen of G-CSF treatment each morning before apheresis and plerixafor treatment in the evening was repeated for up to 5 consecutive days. Mobilization with plerixafor and G-CSF resulted in a median 2.6-fold increase in peripheral blood (PB) CD34+ cell count compared with before plerixafor treatment. All patients collected > or =2 x 10(6) CD34+ cells/kg and 32 of 35 patients collected > or =5 x 10(6) CD34+ cells/kg. After plerixafor treatment, 3 of 7 patients had a small increase and 4 of...
  • Idioma: Inglês

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