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Cortisol secretion and rate of bone loss in a population-based cohort of elderly men and women

Reynolds, R M ; Dennison, E M ; Walker, B R ; Syddall, H E ; Wood, P J ; Andrew, R ; Phillips, D Iw ; Cooper, C

Calcified tissue international, September 2005, Vol.77(3), pp.134-8 [Periódico revisado por pares]

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  • Título:
    Cortisol secretion and rate of bone loss in a population-based cohort of elderly men and women
  • Autor: Reynolds, R M ; Dennison, E M ; Walker, B R ; Syddall, H E ; Wood, P J ; Andrew, R ; Phillips, D Iw ; Cooper, C
  • Assuntos: Bone Density -- Physiology ; Hydrocortisone -- Metabolism ; Hypothalamo-Hypophyseal System -- Physiology ; Osteoporosis, Postmenopausal -- Metabolism ; Pituitary-Adrenal System -- Physiology
  • É parte de: Calcified tissue international, September 2005, Vol.77(3), pp.134-8
  • Descrição: Although excessive glucocorticoids are a well-recognized cause of osteoporosis, little is known about the role of endogenous glucocorticoids in determining skeletal mass. We have performed a detailed study of the hypothalamic-pituitary-adrenal (HPA) axis to explore the relationships between cortisol secretion and adult bone mass in 151 healthy men and 96 healthy women aged 61 to 73 years. At baseline and 4-year follow-up, bone mineral density (BMD) was measured by dual energy X-ray absorptiometry (DXA) at the lumbar spine and proximal femur; a lifestyle questionnaire was completed; and height, weight, and waist and hip circumferences were measured. At follow-up subjects underwent a very low-dose (0.25 mg) dexamethasone suppression test, a low-dose (1 microg) short synacthen test, and a 24-hour urine collection for measurement of cortisol and its metabolites. In men, elevated peak plasma cortisol was associated with accelerated loss of mineral density in the lumbar spine (r = 0.16, P = 0.05)....
  • Idioma: Inglês

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