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Metabolic studies with dinitramine

Kennedy, G L ; Keplinger, M L ; Fancher, O E ; Stone, J D ; Calandra, J C

Toxicology and applied pharmacology, August 1975, Vol.33(2), pp.341-9 [Periódico revisado por pares]

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  • Título:
    Metabolic studies with dinitramine
  • Autor: Kennedy, G L ; Keplinger, M L ; Fancher, O E ; Stone, J D ; Calandra, J C
  • Assuntos: Herbicides -- Metabolism ; Phenylenediamines -- Metabolism
  • É parte de: Toxicology and applied pharmacology, August 1975, Vol.33(2), pp.341-9
  • Descrição: A metabolic study with dinitramine in albino rats showed that the compound is rapidly and extensively metabolized. Unaltered dinitramine was detected only in the feces. Chromatographic analysis suggested the occurrence of multiple metabolites in both feces and urine. None of these were identified. Tissue concentrations of dinitramine and/or its tagged metabolites were low, estimated total recoveries from all tissues being 1.5–1.7% calculated as unaltered dinitramine. Treatment of a dairy cow with a single dose of [ 14C]dinitramine after preconditioning with the unlabeled compound, at levels corresponding to 0.3 ppm in the total diet in each case, gave no detectable concentrations of radioactivity in whole milk and barely detectable amounts in the concentrated lipid fraction. The 14C-activity of all tissues was below the detection limit of 0.36 ppb for 150 mg samples. Only liver samples had counts of 1–3 above background. Exposure of bluegill sunfish to dinitramine revealed...
  • Idioma: Inglês

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