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Reproductive, teratogenic, perinatal and postnatal studies with cyclazocine

Nuite, J A ; Smith, S ; Kennedy, G L ; Keplinger, M L ; Calandra, J C

Toxicology and applied pharmacology, March 1975, Vol.31(3), pp.534-43 [Periódico revisado por pares]

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  • Título:
    Reproductive, teratogenic, perinatal and postnatal studies with cyclazocine
  • Autor: Nuite, J A ; Smith, S ; Kennedy, G L ; Keplinger, M L ; Calandra, J C
  • Assuntos: Cyclazocine -- Pharmacology ; Reproduction -- Drug Effects ; Teratogens -- Pharmacology
  • É parte de: Toxicology and applied pharmacology, March 1975, Vol.31(3), pp.534-43
  • Descrição: Cyclazocine, a mixed narcotic agonist-antagonist, was evaluated for teratogenic effects in rats and rabbits and for effects on reproductive performance, perinatal and postnatal development in rats. To evaluate teratogenic effects, Charles River albino rats were treated orally from days 6 through 15 of gestation with 3, 10, or 30 mg/kg/day of cyclazocine; New Zealand rabbits were dosed orally from days 6 through 18 of gestation with 1, 3, or 10 mg/kg/day. Rats and rabbits were sacrificed on day 20 or day 29 of gestation, respectively. Numbers of implantation sites, resorption sites, corpora lutea, and viable fetuses, as well as external, internal, and skeletal abnormalities were similar in test and control groups. No dose-related, external, internal or skeletal abnormalities were found in the offspring of either species. To evaluate effects on fertility and general reproductive performance, male or female rats were dosed orally for either 63 or 14 days, respectively, prior to mating...
  • Idioma: Inglês

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