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Linear aspects of changes in deoxygenated hemoglobin concentration and cytochrome oxidase oxidation during brain activation

Wobst, P ; Wenzel, R ; Kohl, M ; Obrig, H ; Villringer, A

NeuroImage, March 2001, Vol.13(3), pp.520-30 [Periódico revisado por pares]

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  • Título:
    Linear aspects of changes in deoxygenated hemoglobin concentration and cytochrome oxidase oxidation during brain activation
  • Autor: Wobst, P ; Wenzel, R ; Kohl, M ; Obrig, H ; Villringer, A
  • Assuntos: Magnetic Resonance Imaging ; Spectroscopy, Near-Infrared ; Arousal -- Physiology ; Electron Transport Complex IV -- Metabolism ; Hemoglobins -- Metabolism ; Oxyhemoglobins -- Metabolism ; Visual Cortex -- Physiology
  • É parte de: NeuroImage, March 2001, Vol.13(3), pp.520-30
  • Descrição: We used near infrared spectroscopy (NIRS) to investigate the vascular and metabolic response to brain activation in human primary and adjacent secondary visual cortex. NIRS is able to measure concentration changes in deoxygenated hemoglobin ([deoxy-Hb]) (which mainly contribute to the blood oxygenation level-dependent (BOLD) signal in functional magnetic resonance imaging (fMRI)) as well as concentration changes of oxygenated hemoglobin ([oxy-Hb]) and corpuscular blood volume ([total-Hb] = [oxy-Hb] + [deoxy-Hb]) and changes in the redox status of the cytochrome c oxidase ([Cyt-Ox]), a putative parameter for cellular oxygenation. A sound understanding of the transfer functions between stimulus parameters, neuronal activity, and vascular/metabolic parameters is important for interpretation of data acquired with indirect neuroimaging techniques like fMRI, especially in event-related design studies. In the present study we tested whether the vascular/metabolic response to stimulation can be...
  • Idioma: Inglês

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