skip to main content

Cocaine vaccines: antibody protection against relapse in a rat model

Carrera, M R ; Ashley, J A ; Zhou, B ; Wirsching, P ; Koob, G F ; Janda, K D

Proceedings of the National Academy of Sciences of the United States of America, 23 May 2000, Vol.97(11), pp.6202-6 [Periódico revisado por pares]

Texto completo disponível

Citações Citado por
  • Título:
    Cocaine vaccines: antibody protection against relapse in a rat model
  • Autor: Carrera, M R ; Ashley, J A ; Zhou, B ; Wirsching, P ; Koob, G F ; Janda, K D
  • Assuntos: Vaccines ; Cocaine -- Analogs & Derivatives ; Cocaine-Related Disorders -- Prevention & Control ; Hemocyanins -- Immunology
  • É parte de: Proceedings of the National Academy of Sciences of the United States of America, 23 May 2000, Vol.97(11), pp.6202-6
  • Descrição: The efficacy of active immunization with the cocaine immunogen GNC-keyhole limpet hemocyanin (KLH) in preventing cocaine self-administration reinstatement was assessed in rats. An animal model of relapse was used where rats were trained to self-administer cocaine, subjected to a period of extinction by substituting the drug for saline, vaccinated, and re-exposed to cocaine. Compared with controls, animals immunized with GNC-KLH did not reinstate cocaine self-administration behavior when given a noncontingent cocaine infusion on two consecutive days. Upon double and triple infusions, 38-62% of vaccinated animals failed to reinstate as compared with full reinstatement in all control animals. Exposure to ad libitum cocaine reinstated baseline values in control animals and resulted in double to triple the baseline values of self-infusions in vaccinated animals, suggesting a partial antibody-mediated blockade of cocaine access to the central nervous system. This compensating effect was blocked...
  • Idioma: Inglês

Buscando em bases de dados remotas. Favor aguardar.