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Fumaric acid esters in dermatology

Wollina, Uwe

Indian Dermatology Online Journal, 2011, Vol.2(2), p.111-119 [Periódico revisado por pares]

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  • Título:
    Fumaric acid esters in dermatology
  • Autor: Wollina, Uwe
  • Assuntos: Fumaric acid esters; pharmacology; psoriasis; granulomatous skin diseases; melanoma
  • É parte de: Indian Dermatology Online Journal, 2011, Vol.2(2), p.111-119
  • Descrição: Fumaric acid esters (FAE) are substances of interest in dermatology. FAE exert various activities on cutaneous cells and cytokine networks. So far only a mixture of dimethylfumarate (DMF) and three salts of monoethylfumarate (MEF) have gained approval for the oral treatment of moderate-to-severe plaque-type psoriasis in Germany. DMF seems to be the major active component. There is evidence that FAE are not only effective and safe in psoriasis but granulomatous non-infectious diseases like granuloma annulare, necrobiosis lipoidica and sarcoidosis. In vitro and animal studies suggest some activity in malignant melanoma as well.

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