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The extent of linkage disequilibrium in beef cattle breeds using high-density SNP genotypes

Porto-Neto, Laercio R ; Kijas, James W ; Reverter, Antonio Bmc, Bmc (Editor)

Genetics Selection Evolution, December 2014, Vol.46(1), p.22 [Periódico revisado por pares]

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  • Título:
    The extent of linkage disequilibrium in beef cattle breeds using high-density SNP genotypes
  • Autor: Porto-Neto, Laercio R ; Kijas, James W ; Reverter, Antonio
  • Bmc, Bmc (Editor)
  • Assuntos: Life Sciences ; Agriculture ; Biology
  • É parte de: Genetics Selection Evolution, December 2014, Vol.46(1), p.22
  • Descrição: Background The extent of linkage disequilibrium (LD) between molecular markers impacts genome-wide association studies and implementation of genomic selection. The availability of high-density single nucleotide polymorphism (SNP) genotyping platforms makes it possible to investigate LD at an unprecedented resolution. In this work, we characterised LD decay in breeds of beef cattle of taurine, indicine and composite origins and explored its variation across autosomes and the X chromosome.FindingsIn each breed, LD decayed rapidly and r2 was less than 0.2 for marker pairs separated by 50 kb. The LD decay curves clustered into three groups of similar LD decay that distinguished the three main cattle types. At short distances between markers ( 10 kb), taurine breeds showed higher LD (r2 = 0.45) than their indicine (r2 = 0.25) and composite (r2 = 0.32) counterparts. This higher LD in taurine breeds was attributed to a smaller effective population size and a stronger bottleneck...
  • Idioma: Inglês

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