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Measures of thyroid function among Belarusian children and adolescents exposed to iodine-131 from the accident at the Chernobyl nuclear plant.(Research: Children's Health)(Report)

Ostroumova, Evgenia ; Rozhko, Alexander ; Hatch, Maureen ; Furukawa, Kyoji ; Polyanskaya, Olga ; Mcconnell, Robert J. ; Nadyrov, Eldar ; Petrenko, Sergey ; Romanov, George ; Yauseyenka, Vasilina ; Drozdovitch, Vladimir ; Minenko, Viktor ; Prokopovich, Alexander ; Savasteeva, Irina ; Zablotska, Lydia B. ; Mabuchi, Kiyohiko ; Brenner, Alina V.

Environmental Health Perspectives, 2013, Vol.121(7), p.865 [Periódico revisado por pares]

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  • Título:
    Measures of thyroid function among Belarusian children and adolescents exposed to iodine-131 from the accident at the Chernobyl nuclear plant.(Research: Children's Health)(Report)
  • Autor: Ostroumova, Evgenia ; Rozhko, Alexander ; Hatch, Maureen ; Furukawa, Kyoji ; Polyanskaya, Olga ; Mcconnell, Robert J. ; Nadyrov, Eldar ; Petrenko, Sergey ; Romanov, George ; Yauseyenka, Vasilina ; Drozdovitch, Vladimir ; Minenko, Viktor ; Prokopovich, Alexander ; Savasteeva, Irina ; Zablotska, Lydia B. ; Mabuchi, Kiyohiko ; Brenner, Alina V.
  • Assuntos: Thyroid Gland – Physiological Aspects ; Thyroid Gland – Research ; Children – Health Aspects
  • É parte de: Environmental Health Perspectives, 2013, Vol.121(7), p.865
  • Descrição: BACKGROUND: Thyroid dysfunction after exposure to low or moderate doses of radioactive iodine-131 ([sup.131]I) at a young age is a public health concern. However, quantitative data are sparse concerning [sup.131]I-related risk of these common diseases. OBJECTIVE: Our goal was to assess the prevalence of thyroid dysfunction in association with [sup.131]I exposure during childhood ([less than or equal to] 18 years) due to fallout from the Chernobyl accident. METHODS: We conducted a cross-sectional analysis of hypothyroidism, hyperthyroidism, autoimmune thyroiditis (AIT), serum concentrations of thyroid-stimulating hormone (TSH), and autoantibodies to thyroperoxidase (ATPO) in relation to measurement-based [sup.131]I dose estimates in a Belarusian cohort of 10,827 individuals screened for various thyroid diseases. RESULTS: Mean age at exposure ([+ or -] SD) was 8.2 [+ or -] 5.0 years. Mean (median) estimated [sup.131]I thyroid dose was 0.54 (0.23) Gy (range, 0.001-26.6 Gy). We found significant positive associations of [sup.131]I dose with hypothyroidism (mainly subclinical and antibody-negative) and serum TSH concentration. The excess odds ratio per 1 Gy for hypothyroidism was 0.34 (95% CI: 0.15, 0.62) and varied significantly by age at exposure and at examination, presence of goiter, and urban/rural residency. We found no evidence of positive associations with antibody-positive hypothyroidism, hyperthyroidism, AIT, or elevated ATPO. CONCLUSIONS: The association between [sup.131]I dose and hypothyroidism in the Belarusian cohort is consistent with that previously reported for a Ukrainian cohort and strengthens evidence of the effect of environmental [sup.131]I exposure during childhood on hypothyroidism, but not other thyroid outcomes. KEY WORDS: antithyroid antibodies, autoimmune thyroiditis, Chernobyl, Chornobyl, dose response, hyperthyroidism, hypothyroidism, radioiodine, thyroid gland. Environ Health Perspect 121:865-871 (2013). http://dx.doi.org/10.1289/ehp.1205783 [Online 7 May 2013]
  • Idioma: Inglês

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