skip to main content

Tannic acid-induced apoptosis and -enhanced sensitivity to arsenic trioxide in human leukemia HL-60 cells.(Report)

Chen, Kuo - Shuen ; Hsiao, Yung - Chin ; Kuo, Dong - Yih ; Chou, Ming - Chih ; Chu, Shu - Chen ; Hsieh, Yih - Shou ; Lin, Tseng - Hsi

Leukemia Research, Feb, 2009, Vol.33(2), p.297(11) [Periódico revisado por pares]

Texto completo disponível

Citações Citado por
  • Título:
    Tannic acid-induced apoptosis and -enhanced sensitivity to arsenic trioxide in human leukemia HL-60 cells.(Report)
  • Autor: Chen, Kuo - Shuen ; Hsiao, Yung - Chin ; Kuo, Dong - Yih ; Chou, Ming - Chih ; Chu, Shu - Chen ; Hsieh, Yih - Shou ; Lin, Tseng - Hsi
  • Assuntos: Arsenic Trioxide -- Analysis ; Leukemia -- Analysis ; Cytochrome C -- Analysis ; Cells (Biology) -- Analysis ; Enzymes -- Analysis ; Superoxides -- Analysis ; Monosaccharides -- Analysis ; Apoptosis -- Analysis ; Dermatologic Agents -- Analysis ; Arsenic -- Analysis
  • É parte de: Leukemia Research, Feb, 2009, Vol.33(2), p.297(11)
  • Descrição: To link to full-text access for this article, visit this link: http://dx.doi.org/10.1016/j.leukres.2008.08.006 Byline: Kuo-Shuen Chen (a), Yung-Chin Hsiao (b), Dong-Yih Kuo (c), Ming-Chih Chou (a), Shu-Chen Chu (d), Yih-Shou Hsieh (b), Tseng-Hsi Lin (b)(e) Keywords: Tannic acid; Acute myeloid leukemia cells; Apoptosis; Superoxide; SOD Abstract: Tannic acid (TA), a glucoside of gallic acid polymer, has been shown to possess anti-bacterial, anti-enzymatic, anti-tumor and astringent properties. However, the anti-cancer activity of TA in leukemia is still obscure. In this study, we showed TA-induced apoptotic death in acute myeloid leukemia (AML) HL-60 cells via dose- and time-dependent manner as well as increase of sub-G1 fraction, chromosome condensation, and DNA fragmentation. Further analysis demonstrated the involvement of activation of caspase cascade, cleavage of poly (ADP-ribose) polymerase (PARP), disruption of mitochondrial membrane potential, and release of Cytochrome C, in TA-induced apoptosis. These effects were probably associated with the increase of intracellular superoxide in mitochondrial signaling pathway which attributed to the down-regulation of superoxide dismutase (SOD). Notably, a low dose of TA is sufficient to aggravate arsenic trioxide (As.sub.2O.sub.3)-induced cytotoxicity in HL-60 cells. Altogether, this study suggested the effects of TA to induce apoptosis in HL-60 and therapeutic potential in AML by being an adjunct to As.sub.2O.sub.3. Author Affiliation: (a) Institute of Medicine, Chung Shan Medical University, No. 110 Section 1, Chien Kuo N. Road, Taichung 402, Taiwan (b) Institute of Biochemistry and Biotechnology, Chung Shan Medical University, No. 110 Section 1, Chien Kuo N. Road, Taichung 402, Taiwan (c) Department of Physiology, Chung Shan Medical University, No. 110 Section 1, Chien Kuo N. Road, Taichung 402, Taiwan (d) Institute and Department of Food Science, Central Taiwan University of Science and Technology, No. 11 Pu-Tzu Lane, Pu-Tzu Road, Taichung 406, Taiwan (e) Division of Hematology/Oncology, Department of Internal Medicine, Taichung Veterans General Hospital, No. 160 Section 3, Taichung Kung Road, Taichung, Taiwan Article History: Received 30 April 2008; Revised 3 August 2008; Accepted 4 August 2008
  • Idioma: English

Buscando em bases de dados remotas. Favor aguardar.