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Structural and functional magnetic resonance imaging correlates of motor network dysfunction in primary progressive multiple sclerosis.(Report)

Ceccarelli, Antonia ; Rocca, Maria A. ; Valsasina, Paola ; Rodegher, Mariaemma ; Falini, Andrea ; Comi, Giancarlo ; Filippi, Massimo

European Journal of Neuroscience, April, 2010, Vol.31(7), p.1273(8) [Periódico revisado por pares]

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  • Título:
    Structural and functional magnetic resonance imaging correlates of motor network dysfunction in primary progressive multiple sclerosis.(Report)
  • Autor: Ceccarelli, Antonia ; Rocca, Maria A. ; Valsasina, Paola ; Rodegher, Mariaemma ; Falini, Andrea ; Comi, Giancarlo ; Filippi, Massimo
  • Assuntos: Magnetic Resonance Imaging ; Multiple Sclerosis
  • É parte de: European Journal of Neuroscience, April, 2010, Vol.31(7), p.1273(8)
  • Descrição: To authenticate to the full-text of this article, please visit this link: http://dx.doi.org/10.1111/j.1460-9568.2010.07147.x Byline: Antonia Ceccarelli (1), Maria A. Rocca (1,2), Paola Valsasina (1), Mariaemma Rodegher (2), Andrea Falini (3), Giancarlo Comi (2), Massimo Filippi (1,2) Keywords: diffusion tensor tractography; functional connectivity; functional MRI; motor network; primary progressive multiple sclerosis Abstract: Abstract We combined functional magnetic resonance imaging (fMRI) and diffusion tensor tractography to investigate the functional and structural substrates of motor network dysfunction in patients with primary progressive multiple sclerosis (PPMS). In 15 right-handed PPMS patients and 15 age-matched healthy controls, we acquired diffusion tensor magnetic resonance imaging and fMRI during the performance of a simple motor task. Tractography was used to calculate diffusion tensor-derived measures of the corpus callosum, the corticospinal tract, the optic radiation, the fronto-occipital fasciculus, and the inferior longitudinal fasciculus. Analyses of fMRI activations and functional connectivity were performed using statistical parametric mapping (cluster threshold of P = 0.001, and extent cluster threshold of 10 voxels for comparison of activations; P < 0.05, family-wise error corrected for functional connectivity). As compared with controls, PPMS patients had more significant activations of the left postcentral gyrus, left secondary sensorimotor area, left parahippocampal gyrus, left cerebellum, right primary sensorimotor cortex (SMC), right basal ganglia, right insula, right cingulum, and cuneus bilaterally. As compared with PPMS patients, controls had increased functional connectivity between the left primary SMC and the ipsilateral inferior frontal gyrus. Conversely, PPMS patients showed increased functional connectivity between the left primary SMC and the right cuneus. Moderate correlations were found between functional activations and damage to the tracts studied (r-values between 0.82 and 0.84; P < 0.001). These results suggest that, as compared with healthy controls, PPMS patients show increased activations and abnormal functional connectivity measures in several areas of the sensorimotor network. Such changes are correlated with the structural damage to the white matter fiber bundles connecting these regions. Author Affiliation: (1)Neuroimaging Research Unit, Institute of Experimental Neurology, Scientific Institute and University Ospedale San Raffaele, Via Olgettina, 60, 20132 Milan, Italy (2)Department of Neurology, Institute of Experimental Neurology, Scientific Institute and University Ospedale San Raffaele, Milan, Italy (3)Department of Neuroradiology, Scientific Institute and University Ospedale San Raffaele, Milan, Italy Article History: Received 14 September 2009, revised 7 January 2010, accepted 20 January 2010 Article note: Dr M. Filippi, 1Neuroimaging Research Unit, as above., E-mail: filippi.massimo@hsr.it
  • Idioma: English

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