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Type IV SCCmec found in decade old Brazilian MRSA isolates.(staphylococcal cassette chromosome mec)(methicillin-resistant Staphylococcus aureus)(Report)

Reinert, Cristina ; Mcculloch, John Anthony ; Watanabe, Shinya ; Ito, Teruyo ; Hiramatsu, Keiichi ; Mamizuka, Elsa Masae

The Brazilian Journal of Infectious Diseases, June, 2008, Vol.12(3), p.213(4) [Periódico revisado por pares]

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  • Título:
    Type IV SCCmec found in decade old Brazilian MRSA isolates.(staphylococcal cassette chromosome mec)(methicillin-resistant Staphylococcus aureus)(Report)
  • Autor: Reinert, Cristina ; Mcculloch, John Anthony ; Watanabe, Shinya ; Ito, Teruyo ; Hiramatsu, Keiichi ; Mamizuka, Elsa Masae
  • Assuntos: Genes -- Physiological Aspects ; Genes -- Research ; Staphylococcus Aureus -- Genetic Aspects ; Staphylococcus Aureus -- Health Aspects ; Staphylococcus Aureus -- Research ; Staphylococcus Aureus Infections -- Causes Of ; Staphylococcus Aureus Infections -- Genetic Aspects ; Staphylococcus Aureus Infections -- Research
  • É parte de: The Brazilian Journal of Infectious Diseases, June, 2008, Vol.12(3), p.213(4)
  • Descrição: Methicillin-resistant Staphylococcus aureus (MRSA) commonly causes infection in hospitalized patients. Since its appearance in the 1960s, the SCCmec has evolved throughout the years into 5 different types (I-V), each bearing a different set of genes. Infection with MRSA SCCmec types I, II or III is almost exclusively restricted to hospitalised patients. However, recently, community acquired MRSA (CA-MRSA) infections have been reported with increasing frequency, usually caused by a type IV SCCmec MRSA in nosocomial settings. We studied the prevalence of SCCmec types in 50 nosocomial strains collected from 1995 to 1999. The SCCmec complex type and presence of Panton-Valentine leukocidin (PVL) were determined by PCR. Strains had been previously typed by PFGE and were now typed by MLST. We found that 3 of the isolates studied bore a type IVc SCCmec all having different PFGE and MLST profiles (ST3, ST5 and ST88). All strains bearing a type III SCCmec belonged to MLST ST239 (Brazilian/Iberian clone). Only the strain which presented the ST5 profile bore the pvl gene. The type IVc SCCmec strains presented relatively lower levels of resistance to oxacillin in comparison to the type III SCCmec strains. The pattern of dissemination of the type IV SCCmec remains to be elucidated. The finding of strains carrying a type IV SCCmec in the present study among strains isolated at least 7 years ago indicates that clones bearing a type IV SCCmec have been present in Brazil for quite some time, and must have gone by undetected. Key-Words: Nosocomial infections, type IV SCCmec, Staphylococcus aureus, methicillin-resistant, Brazil.
  • Idioma: English
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  • Realização: AGUIA USP

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