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Subclinical hypothyroidism after radioiodine exposure: Ukrainian-American cohort study of thyroid cancer and other thyroid diseases after the Chornobyl accident (1998-2000).(Research)(Report)

Ostroumova, Evgenia ; Brenner, Alina ; Oliynyk, Valery ; Mcconnell, Robert ; Robbins, Jacob ; Terekhova, Galina ; Zablotska, Lydia ; Likhtarev, Llya ; Bouville, Andre ; Shpak, Viktor ; Markov, Valentin ; Masnyk, Ihor ; Ron, Elaine ; Tronko, Mykola ; Hatch, Maureen

Environmental Health Perspectives, May, 2009, Vol.117(5), p.745(6) [Periódico revisado por pares]

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  • Título:
    Subclinical hypothyroidism after radioiodine exposure: Ukrainian-American cohort study of thyroid cancer and other thyroid diseases after the Chornobyl accident (1998-2000).(Research)(Report)
  • Autor: Ostroumova, Evgenia ; Brenner, Alina ; Oliynyk, Valery ; Mcconnell, Robert ; Robbins, Jacob ; Terekhova, Galina ; Zablotska, Lydia ; Likhtarev, Llya ; Bouville, Andre ; Shpak, Viktor ; Markov, Valentin ; Masnyk, Ihor ; Ron, Elaine ; Tronko, Mykola ; Hatch, Maureen
  • Assuntos: Hypothyroidism -- Risk Factors ; Hypothyroidism -- Research ; Radioiodine -- Environmental Aspects ; Radioiodine -- Health Aspects ; Radioiodine -- Research ; Prevalence Studies (Epidemiology)
  • É parte de: Environmental Health Perspectives, May, 2009, Vol.117(5), p.745(6)
  • Descrição: Background: Hypothyroidism is the most common thyroid abnormality in patients treated with high doses of iodine-131 ( super(131)I). Data on risk of hypothyroidism from low to moderate super(131)I thyroid doses are limited and inconsistent. Objective: This study was conducted to quantify the risk of hypothyroidism prevalence in relation to super(131)I doses received because of the Chornobyl accident. Methods: This is a cross-sectional (1998-2000) screening study of thyroid diseases in a cohort of 11,853 individuals < 18 years of age at the time of the accident, with individual thyroid radioactivity measurements taken within 2 months of the accident. We measured thyroid-stimulating hormone (TSH), free thyroxine, and antibodies to thyroid peroxidase (ATPO) in serum. Results: Mean age at examination of the analysis cohort was 21.6 years (range, 12.2-32.5 years), with 49% females. Mean super(131)I thyroid dose was 0.79 Gy (range, 0-40.7 Gy). There were 719 cases with hypothyroidism (TSH > 4 mIU/L), including 14 with overt hypothyroidism. We found a significant, small association between super(131)I thyroid doses and prevalent hypothyroidism, with the excess odds ratio (EOR) per gray of 0.10 (95% confidence interval, 0.03-0.21). EOR per gray was higher in individuals with ATPO , 60 U/mL compared with individuals with ATPO > 60 U/mL (p < 0.001). Conclusions: This is the first study to find a significant relationship between prevalence of hypothyroidism and individual super(131)I thyroid doses due to environmental exposure. The radiation increase in hypothyroidism was small (10% per Gy) and limited largely to subclinical hypothyroidism. Prospective data are needed to evaluate the dynamics of radiation-related hypothyroidism and clarify the role of antithvroid antibodies.
  • Idioma: English

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