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Tissue-specific gene regulation corresponds with seasonal plasticity in female testosterone

Bentz, Alexandra B ; Dossey, Emma K ; Rosvall, Kimberly A

General and Comparative Endocrinology, 01 January 2019, Vol.270, pp.26-34 [Periódico revisado por pares]

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  • Título:
    Tissue-specific gene regulation corresponds with seasonal plasticity in female testosterone
  • Autor: Bentz, Alexandra B ; Dossey, Emma K ; Rosvall, Kimberly A
  • Assuntos: 5-Alpha Reductase ; Steroidogenic Acute Regulatory Protein ; Cyp17 ; 3βhsd ; Luteinizing Hormone Receptor ; Cyp2c19 ; Medicine ; Anatomy & Physiology
  • É parte de: General and Comparative Endocrinology, 01 January 2019, Vol.270, pp.26-34
  • Descrição: Testosterone (T) is a sex steroid hormone that often varies seasonally and mediates trade-offs between territorial aggression and parental care. Prior work has provided key insights into the ‘top-down’ hypothalamic control of this seasonal plasticity in T, yet mechanisms acting outside of the brain may also influence circulating T levels. We hypothesized that peripheral mechanisms may be especially critical for females, because peripheral regulation may mitigate the costs of systemically elevated T. Here, we begin to test this hypothesis using a seasonal comparative approach, measuring gene expression in peripheral tissues in tree swallows ( ), a songbird with intense female-female competition and T-mediated aggression. We focused on the gonad and liver for their role in T production and metabolism, respectively, and we contrasted females captured during territory establishment versus incubation. During territory establishment, when T levels are highest, we...
  • Idioma: Inglês

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