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Differential effects of homotypic vs. heterotypic chronic stress regimens on microglial activation in the prefrontal cortex

Kopp, Brittany L ; Wick, Dayna ; Herman, James P

Physiology & Behavior, 02 October 2013, Vol.122, pp.246-252 [Periódico revisado por pares]

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  • Título:
    Differential effects of homotypic vs. heterotypic chronic stress regimens on microglial activation in the prefrontal cortex
  • Autor: Kopp, Brittany L ; Wick, Dayna ; Herman, James P
  • Assuntos: Microglia ; Prefrontal Cortex ; Chronic Stress ; Iba-1 ; Glucocorticoids ; Microglia ; Prefrontal Cortex ; Chronic Stress ; Iba-1 ; Glucocorticoids ; Anatomy & Physiology ; Psychology
  • É parte de: Physiology & Behavior, 02 October 2013, Vol.122, pp.246-252
  • Descrição: Stress pathology is associated with hypothalamic–pituitary–adrenal (HPA) axis dysregulation and aberrant glucocorticoid responses. Recent studies indicate increases in prefrontal cortical ionized calcium-binding adapter molecule 1 (Iba-1) staining following repeated restraint, reflecting increased microglial densities. Our experiments tested expression of Iba-1 staining in the prelimbic cortex (PL), infralimbic cortex (IL) and the hypothalamic paraventricular nucleus (PVN) following two-week exposure to repeated restraint (RR) and chronic variable stress (CVS), representing homotypic and heterotypic regimens, respectively. Unstressed animals served as controls. We specifically examined Iba-1 immunofluorescence in layers 2 and 3 versus layers 5 and 6 of the PL and IL, using both cell number and field staining density. Iba-1 field staining density was increased in both the PL and IL following RR in comparison to controls. This effect was not observed following CVS. Furthermore,...
  • Idioma: Inglês

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