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Evaluation of the anticocaine monoclonal antibody GNC92H2 as an immunotherapy for cocaine overdose

Carrera, M. Rocío A ; Trigo, José Manuel ; Wirsching, Peter ; Roberts, Amanda J ; Janda, Kim D

Pharmacology, Biochemistry and Behavior, 2005, Vol.81(4), pp.709-714 [Periódico revisado por pares]

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  • Título:
    Evaluation of the anticocaine monoclonal antibody GNC92H2 as an immunotherapy for cocaine overdose
  • Autor: Carrera, M. Rocío A ; Trigo, José Manuel ; Wirsching, Peter ; Roberts, Amanda J ; Janda, Kim D
  • Assuntos: Cocaine-Induced Toxicity ; Monoclonal Antibody ; Gnc92h2 ; Mice ; Immunotherapy ; Cocaine-Induced Toxicity ; Monoclonal Antibody ; Gnc92h2 ; Mice ; Immunotherapy ; Pharmacy, Therapeutics, & Pharmacology ; Psychology
  • É parte de: Pharmacology, Biochemistry and Behavior, 2005, Vol.81(4), pp.709-714
  • Descrição: The illicit use of cocaine continues in epidemic proportions and treatment for cocaine overdose remains elusive. Current protein-based technology offers a new therapeutic venue by which antibodies bind the drug in the blood stream, inactivating its toxic effects. The therapeutic potential of the anticocaine antibody GNC92H2 was examined using a model of cocaine overdose. Swiss albino mice prepared with intrajugular catheters were tested in photocell cages after administration of 93 mg/kg (LD 50) of cocaine and GNC92H2 infusions ranging from 30 to 190 mg/kg. GNC92H2 was delivered 30 min before, concomitantly or 3 min after cocaine treatment. Significant blockade of cocaine toxicity was observed with the higher dose of GNC92H2 (190 mg/kg), where premorbid behaviors were reduced up to 40%, seizures up to 77% and death by 72%. Importantly, GNC92H2 prevented death even post-cocaine injection. The results support the important potential of GNC92H2 as a therapeutic tool against cocaine...
  • Idioma: Inglês

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