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Differential DJ-1 gene expression in Parkinson's disease

Kumaran, Ravindran ; Vandrovcova, Jana ; Luk, Connie ; Sharma, Simone ; Renton, Alan ; Wood, Nicholas W ; Hardy, John A ; Lees, Andrew J ; Bandopadhyay, Rina

Neurobiology of Disease, 2009, Vol.36(2), pp.393-400 [Periódico revisado por pares]

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  • Título:
    Differential DJ-1 gene expression in Parkinson's disease
  • Autor: Kumaran, Ravindran ; Vandrovcova, Jana ; Luk, Connie ; Sharma, Simone ; Renton, Alan ; Wood, Nicholas W ; Hardy, John A ; Lees, Andrew J ; Bandopadhyay, Rina
  • Assuntos: Dj-1 Mrna ; Parkinson'S Disease ; Quantitative Real-Time Pcr ; Post-Mortem Human Brain ; Medicine ; Anatomy & Physiology
  • É parte de: Neurobiology of Disease, 2009, Vol.36(2), pp.393-400
  • Descrição: Mutations in the gene have been linked with rare cases of early onset, autosomal recessive Parkinson's disease (PD). To determine whether DJ-1 is also involved in the pathogenesis of common forms of PD we have compared DJ-1 mRNA levels in a number of post-mortem PD and control brain regions using quantitative real-time PCR. Region-specific decreases were observed in DJ-1 mRNA levels in putamen, frontal cortex, parietal cortex and cerebellum in PD (∼ 30–60%) compared to controls whilst an up-regulation was observed in the amygdala (∼ 90%) and entorhinal cortex (∼ 39%). Using quantitative western blot analysis, parallel decreases in DJ-1 protein levels were seen in frontal cortex, putamen and cerebellum of PD cases. By using 2-dimensional gel electrophoresis, we show preponderance of acidic pI isoforms of DJ-1 monomer in PD vulnerable regions, namely frontal cortex and medulla suggestive...
  • Idioma: Inglês

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