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The potential of arsenic trioxide in the treatment of malignant disease: past, present, and future

Evens, Andrew M ; Tallman, Martin S ; Gartenhaus, Ronald B

Leukemia Research, 2004, Vol.28(9), pp.891-900 [Periódico revisado por pares]

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  • Título:
    The potential of arsenic trioxide in the treatment of malignant disease: past, present, and future
  • Autor: Evens, Andrew M ; Tallman, Martin S ; Gartenhaus, Ronald B
  • Assuntos: Arsenic Trioxide ; Acute Promyelocytic Leukemia ; Pharmacologic Modulation ; Arsenic Trioxide ; Acute Promyelocytic Leukemia ; Pharmacologic Modulation ; Medicine
  • É parte de: Leukemia Research, 2004, Vol.28(9), pp.891-900
  • Descrição: Arsenic trioxide (As 2O 3) is an effective therapy for acute promyelocytic leukemia (APL), and there has been promising activity noted in other hematologic and solid tumors. The mechanism of action of As 2O 3 such as differentiation and apoptosis has prompted study into combination therapy. Furthermore, the connection of the sensitivity of diseases such as APL and multiple myeloma to oxidative damage has allowed the investigation of pharmacologic modulation of the cellular redox state for potentiation of As 2O 3. Continued study of As 2O 3 as a single-agent and in combination therapy will allow identification of the safest and most effective treatment regimens for malignant disease.
  • Idioma: Inglês

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