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Treatment of persistent and recurrent acromegaly

Del Porto, Lana A ; Liubinas, Simon V ; Kaye, Andrew H

Journal of Clinical Neuroscience, 2011, Vol.18(2), pp.181-190 [Periódico revisado por pares]

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  • Título:
    Treatment of persistent and recurrent acromegaly
  • Autor: Del Porto, Lana A ; Liubinas, Simon V ; Kaye, Andrew H
  • Assuntos: Acromegaly ; Persistent ; Recurrent ; Radiotherapy ; Radiosurgery ; Somatostatin Analogues ; Transsphenoidal ; Medicine
  • É parte de: Journal of Clinical Neuroscience, 2011, Vol.18(2), pp.181-190
  • Descrição: Acromegaly is a chronic insidious disease characterised by growth hormone (GH) hypersecretion, typically from a pituitary adenoma. Effective treatment of acromegaly is vital because it is associated with a mortality rate more than twice that of the general population, an increased prevalence of colonic malignancy and many significant co-morbidities. Transsphenoidal adenoma resection is still the best first-line treatment for acromegaly but persistence (43%) or recurrence (2% to 3%) of GH hypersecretion after surgery remains a problem. Treatment options for acromegaly after failed initial therapy or recurrence include further surgery, radiotherapy, radiosurgery or medical therapies, including somatostatin analogues, dopamine agonists and growth hormone receptor antagonists. There has been a progressive lowering of the accepted GH level defining cure in acromegaly. This article reviews the efficacy and safety of the various treatment options for persistent or recurrent acromegaly...
  • Idioma: Inglês

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